Peripheral T-cell lymphomas

Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification

Edward R. Arrowsmith, William R. Macon, Marsha C Kinney, Richard S. Stein, Stacey A. Goodman, David S. Morgan, John M. Flexner, John B. Cousar, Madan H. Jagasia, Thomas L. McCurley, John P. Greer

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The purpose of this study was to better define the clinical features and natural history of peripheral T-cell lymphomas (PTCL) entities included in the Revised European American lymphoma (REAL) classification. Cases of PTCL were retrieved from the records of the Department of Pathology and classified according to the REAL classification. In addition, cases of anaplastic large cell lymphoma (ALCL) were divided into classical, small cell, and primary cutaneous subtypes, and immunostaining for the anaplastic large-cell kinase (ALK) protein was performed on all cases of ALCL. Clinical features, response to therapy and survival were abstracted. Ninety-two cases of PTCL with adequate clinical information were retrieved. There were 40 cases of ALCL (30 classical, 7 small cell variant, 3 primary cutaneous), 28 PTCL, unspecified, 13 angioimmunoblastic T-cell lymphoma and 11 with other entities. The patients had a median age of 48 years with a range of 6-84 and had an estimated overall survival (OS) of 49% and progression-free survival (PFS) of 22% at 5 years. The International Prognostic Index (IPI) was a significant prognostic factor for both progression-free and OS. Histology was a significant predictor of PFS with anaplastic large cell having the best prognosis. ALK expression was not associated with an improved progression-free or overall-survival in patients with systemic T-cell ALCL. In conclusion, the REAL classification describes distinct PTCL entities. The IPI is the most important predictor of progression-free and OS in patients with PTCL. ALK expression may not provide prognostic information for systemic ALCL.

Original languageEnglish (US)
Pages (from-to)241-250
Number of pages10
JournalLeukemia and Lymphoma
Volume44
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

Fingerprint

Peripheral T-Cell Lymphoma
Anaplastic Large-Cell Lymphoma
Lymphoma
Disease-Free Survival
T-Cell Lymphoma
Survival
Phosphotransferases
Skin
Protein Kinases
Histology
Pathology

Keywords

  • Clinical features
  • Malignant lymphoma
  • Peripheral T-cell lymphoma
  • Prognostic factors
  • REAL classification

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Peripheral T-cell lymphomas : Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification. / Arrowsmith, Edward R.; Macon, William R.; Kinney, Marsha C; Stein, Richard S.; Goodman, Stacey A.; Morgan, David S.; Flexner, John M.; Cousar, John B.; Jagasia, Madan H.; McCurley, Thomas L.; Greer, John P.

In: Leukemia and Lymphoma, Vol. 44, No. 2, 01.02.2003, p. 241-250.

Research output: Contribution to journalArticle

Arrowsmith, ER, Macon, WR, Kinney, MC, Stein, RS, Goodman, SA, Morgan, DS, Flexner, JM, Cousar, JB, Jagasia, MH, McCurley, TL & Greer, JP 2003, 'Peripheral T-cell lymphomas: Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification', Leukemia and Lymphoma, vol. 44, no. 2, pp. 241-250. https://doi.org/10.1080/1042819021000030054
Arrowsmith, Edward R. ; Macon, William R. ; Kinney, Marsha C ; Stein, Richard S. ; Goodman, Stacey A. ; Morgan, David S. ; Flexner, John M. ; Cousar, John B. ; Jagasia, Madan H. ; McCurley, Thomas L. ; Greer, John P. / Peripheral T-cell lymphomas : Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification. In: Leukemia and Lymphoma. 2003 ; Vol. 44, No. 2. pp. 241-250.
@article{8d033b0baeec4b178e0dc8d3535b23c7,
title = "Peripheral T-cell lymphomas: Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification",
abstract = "The purpose of this study was to better define the clinical features and natural history of peripheral T-cell lymphomas (PTCL) entities included in the Revised European American lymphoma (REAL) classification. Cases of PTCL were retrieved from the records of the Department of Pathology and classified according to the REAL classification. In addition, cases of anaplastic large cell lymphoma (ALCL) were divided into classical, small cell, and primary cutaneous subtypes, and immunostaining for the anaplastic large-cell kinase (ALK) protein was performed on all cases of ALCL. Clinical features, response to therapy and survival were abstracted. Ninety-two cases of PTCL with adequate clinical information were retrieved. There were 40 cases of ALCL (30 classical, 7 small cell variant, 3 primary cutaneous), 28 PTCL, unspecified, 13 angioimmunoblastic T-cell lymphoma and 11 with other entities. The patients had a median age of 48 years with a range of 6-84 and had an estimated overall survival (OS) of 49{\%} and progression-free survival (PFS) of 22{\%} at 5 years. The International Prognostic Index (IPI) was a significant prognostic factor for both progression-free and OS. Histology was a significant predictor of PFS with anaplastic large cell having the best prognosis. ALK expression was not associated with an improved progression-free or overall-survival in patients with systemic T-cell ALCL. In conclusion, the REAL classification describes distinct PTCL entities. The IPI is the most important predictor of progression-free and OS in patients with PTCL. ALK expression may not provide prognostic information for systemic ALCL.",
keywords = "Clinical features, Malignant lymphoma, Peripheral T-cell lymphoma, Prognostic factors, REAL classification",
author = "Arrowsmith, {Edward R.} and Macon, {William R.} and Kinney, {Marsha C} and Stein, {Richard S.} and Goodman, {Stacey A.} and Morgan, {David S.} and Flexner, {John M.} and Cousar, {John B.} and Jagasia, {Madan H.} and McCurley, {Thomas L.} and Greer, {John P.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1080/1042819021000030054",
language = "English (US)",
volume = "44",
pages = "241--250",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Peripheral T-cell lymphomas

T2 - Clinical features and prognostic factors of 92 cases defined by the revised European American lymphoma classification

AU - Arrowsmith, Edward R.

AU - Macon, William R.

AU - Kinney, Marsha C

AU - Stein, Richard S.

AU - Goodman, Stacey A.

AU - Morgan, David S.

AU - Flexner, John M.

AU - Cousar, John B.

AU - Jagasia, Madan H.

AU - McCurley, Thomas L.

AU - Greer, John P.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - The purpose of this study was to better define the clinical features and natural history of peripheral T-cell lymphomas (PTCL) entities included in the Revised European American lymphoma (REAL) classification. Cases of PTCL were retrieved from the records of the Department of Pathology and classified according to the REAL classification. In addition, cases of anaplastic large cell lymphoma (ALCL) were divided into classical, small cell, and primary cutaneous subtypes, and immunostaining for the anaplastic large-cell kinase (ALK) protein was performed on all cases of ALCL. Clinical features, response to therapy and survival were abstracted. Ninety-two cases of PTCL with adequate clinical information were retrieved. There were 40 cases of ALCL (30 classical, 7 small cell variant, 3 primary cutaneous), 28 PTCL, unspecified, 13 angioimmunoblastic T-cell lymphoma and 11 with other entities. The patients had a median age of 48 years with a range of 6-84 and had an estimated overall survival (OS) of 49% and progression-free survival (PFS) of 22% at 5 years. The International Prognostic Index (IPI) was a significant prognostic factor for both progression-free and OS. Histology was a significant predictor of PFS with anaplastic large cell having the best prognosis. ALK expression was not associated with an improved progression-free or overall-survival in patients with systemic T-cell ALCL. In conclusion, the REAL classification describes distinct PTCL entities. The IPI is the most important predictor of progression-free and OS in patients with PTCL. ALK expression may not provide prognostic information for systemic ALCL.

AB - The purpose of this study was to better define the clinical features and natural history of peripheral T-cell lymphomas (PTCL) entities included in the Revised European American lymphoma (REAL) classification. Cases of PTCL were retrieved from the records of the Department of Pathology and classified according to the REAL classification. In addition, cases of anaplastic large cell lymphoma (ALCL) were divided into classical, small cell, and primary cutaneous subtypes, and immunostaining for the anaplastic large-cell kinase (ALK) protein was performed on all cases of ALCL. Clinical features, response to therapy and survival were abstracted. Ninety-two cases of PTCL with adequate clinical information were retrieved. There were 40 cases of ALCL (30 classical, 7 small cell variant, 3 primary cutaneous), 28 PTCL, unspecified, 13 angioimmunoblastic T-cell lymphoma and 11 with other entities. The patients had a median age of 48 years with a range of 6-84 and had an estimated overall survival (OS) of 49% and progression-free survival (PFS) of 22% at 5 years. The International Prognostic Index (IPI) was a significant prognostic factor for both progression-free and OS. Histology was a significant predictor of PFS with anaplastic large cell having the best prognosis. ALK expression was not associated with an improved progression-free or overall-survival in patients with systemic T-cell ALCL. In conclusion, the REAL classification describes distinct PTCL entities. The IPI is the most important predictor of progression-free and OS in patients with PTCL. ALK expression may not provide prognostic information for systemic ALCL.

KW - Clinical features

KW - Malignant lymphoma

KW - Peripheral T-cell lymphoma

KW - Prognostic factors

KW - REAL classification

UR - http://www.scopus.com/inward/record.url?scp=0037300483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037300483&partnerID=8YFLogxK

U2 - 10.1080/1042819021000030054

DO - 10.1080/1042819021000030054

M3 - Article

VL - 44

SP - 241

EP - 250

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 2

ER -