The 'lethargic' mouse is a mutant displaying abnormal neurological behavior. We have demonstrated that this mouse has a peripheral neuropathy with slowed motor nerve conduction velocity (MNCV), prolonged distal motor latency (DML) and reduced evoked muscle potential amplitude (EMPA). In this study, the parabiotic technique, which established cross circulation between two mice, was employed to determine whether there is a pathogenic circulating factor. MNCV and DML in the tail nerve and the EMPA were measured weekly in an experimental group of 20 pairs of normal and 'lethargic' mice. The findings were compared to those of the controls which consisted of 15 pairs of normal and normal mice and 14 pairs of 'lethargic' and 'lethargic' mice. Data analysis showed no statistically significant change in MNCV, DML, or EMPA in the 'lethargic' or normal mice when they were united. These results do not permit one to suggest that there is a circulating factor involved in this neuropathy.
|Original language||English (US)|
|Number of pages||8|
|Journal||Electromyography and Clinical Neurophysiology|
|State||Published - 1981|
ASJC Scopus subject areas
- Clinical Neurology
- Physiology (medical)