Peripheral levels of sST2 are increased in patients with temporal lobe epilepsy: Additional evidence of low-grade inflammation

Eliana Cristina de Brito Toscano, João Marcelo Korcsik Lessa, Guilherme Nogueira de Oliveira, Ana Paula Gonçalves, Érica Leandro Marciano Vieira, Milene Alvarenga Rachid, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Inflammation plays a pivotal role in temporal lobe epilepsy (TLE) pathophysiology. IL-33 can act as a transcription factor or as a cytokine, the latter through the transmembrane ST2 receptor or its soluble isoform (sST2), presenting a dual role in neurological diseases. The aim of this study was to determine the plasma levels of IL-33 and sST2 in parallel with clinical features in patients with TLE. Peripheral blood from patients and controls was sampled for the measurement of plasma levels of IL-33 and sST2 by enzyme-linked immunoassay (ELISA). While there were similar levels of IL-33 between controls and patients, sST2 were increased in patients. IL33 and sST2 plasma levels were not associated with TLE-related clinical features. In a subgroup analysis, IL-33 levels correlated with memory performance. In conclusion, our results reinforce the concept of chronic low-grade inflammation in patients with TLE.

Original languageEnglish (US)
Article number107351
JournalEpilepsy and Behavior
Volume112
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • IL-33
  • Memory
  • Neuroinflammation
  • Temporal lobe epilepsy
  • sST2

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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