TY - JOUR
T1 - Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson's disease
AU - Rocha, Natalia Pessoa
AU - Scalzo, Paula Luciana
AU - Barbosa, Izabela Guimarães
AU - de Campos-Carli, Salvina Maria
AU - Tavares, Lívia Duarte
AU - de Souza, Mariana Soares
AU - Christo, Paulo Pereira
AU - Reis, Helton José
AU - Simões e Silva, Ana Cristina
AU - Teixeira, Antônio Lúcio
N1 - Publisher Copyright:
© 2016
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Background The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin-converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions This is the first study showing that peripheral levels of RAS components are changed in PD and associated with depressive symptoms.
AB - Background The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin-converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions This is the first study showing that peripheral levels of RAS components are changed in PD and associated with depressive symptoms.
KW - Cognition
KW - Depression
KW - Non-motor symptoms
KW - Parkinson's disease
KW - Renin-angiotensin system
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U2 - 10.1016/j.jns.2016.07.031
DO - 10.1016/j.jns.2016.07.031
M3 - Article
C2 - 27538640
AN - SCOPUS:84978288685
SN - 0022-510X
VL - 368
SP - 235
EP - 239
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -