Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson's disease

Natalia Pessoa Rocha, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Salvina Maria de Campos-Carli, Lívia Duarte Tavares, Mariana Soares de Souza, Paulo Pereira Christo, Helton José Reis, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin-converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions This is the first study showing that peripheral levels of RAS components are changed in PD and associated with depressive symptoms.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalJournal of the Neurological Sciences
StatePublished - Sep 15 2016
Externally publishedYes


  • Cognition
  • Depression
  • Non-motor symptoms
  • Parkinson's disease
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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