Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest

Anderson H. Kuo, Cun Li, Hillary F. Huber, Peter W. Nathanielsz, Geoffrey D. Clarke

Research output: Contribution to journalArticlepeer-review

Abstract

Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertension, hypertension, diabetes, hyperlipidemia, and atherosclerosis. We have reported cardiovascular dysfunction in a cohort of maternal nutrient reduction (MNR)-induced intrauterine growth restriction (IUGR) baboon offspring. Here we test the hypothesis that there is oral capillary rarefaction associated with MNR-induced IUGR. Capillary density was quantified using in vivo high-power capillaroscopy on seven middle-aged (~10.7 yr; human equivalent ~40 yr) male IUGR baboons and seven male age-matched controls in the lateral buccal and inferior labial mucosa. While no difference was found between groups in either area by fraction area or optical density for these vascular beds derived from fetal preductal vessels, further studies are needed on post-ductal vascular beds, retina, and function.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalJournal of developmental origins of health and disease
Volume12
Issue number3
DOIs
StatePublished - Jun 2021
Externally publishedYes

Keywords

  • Maternal nutrient reduction
  • baboons
  • capillary density
  • developmental programming
  • intrauterine growth restriction (IUGR)

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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