Perfusion of melatonin into the prefrontal cortex disrupts the circadian rhythm of acetylcholine but not of locomotor activity

Blanca Marquez De Prado, Russel J. Reiter, Francisco Mora

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Extracellular concentrations of acetylcholine (ACh) in the prefrontal cortex displayed a circadian rhythm, with a maximum increase in the dark phase of the light:dark cycle. The increase in ACh related well to the circadian rhythm of the same rats in which a maximal increase of locomotor activity in the dark phase also was observed. Local perfusion of melatonin (200-500 μM), in a dose-dependent manner, disrupted the ACh rhythm in the prefrontal cortex but did not affect the circadian rhythm of locomotor activity. It is suggested that the change in the cholinergic transmission during a circadian period in the prefrontal cortex may be under the control of the biological clock through the action of melatonin; however, the prefrontal cortical ACh cycle seems not to be related to the regulation of locomotor activity.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalJournal of pineal research
Volume35
Issue number4
DOIs
StatePublished - Nov 2003

Keywords

  • Acetylcholine
  • Circadian rhythms
  • Locomotor activity
  • Melatonin
  • Prefrontal cortex

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Perfusion of melatonin into the prefrontal cortex disrupts the circadian rhythm of acetylcholine but not of locomotor activity'. Together they form a unique fingerprint.

Cite this