Performance of PAC1-R heterozygous mice in memory tasks-II

Nobuyoshi Hagino

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


An involvement of pituitary adenylate cyclase activating polypeptide-specific receptor type 1 (PAC1-R) in behavioral performance of retrieval of memory upon the stimulation of perception of sensory modality was investigated in mice. Eighteen heterozygous (-/+) transgenic mutant PAC1-R-deficient mice {(-/+) mice} and 18 wild-type (+/+) mice of littermates {(+/+) mice} as a control were used. No homozygous (-/-) transgenic mutant PAC1-R-deficit mouse was bred in our colony. It was observed that; (1) changing a single alley in the multiple mazes interfered with retrieval of memory in both (-/+) mice and (+/+) mice, and they made considerable errors; (2) a rotation of the multiple mazes for 180° in relation to the geomagnetic field made also considerable errors, but in only (+/+) mice and not in (-/+) mice; and (3) an exposure for perception of fear signals made also considerable errors, but in only (+/+) mice and not in (-/+) mice. It is inferred that PAC1-R may play a gating role in passage permitting through perception of geomagnetic orientation and fear signals, but not perception of visual orientation, and it regulates behavioral performance in retrieval of memory in mice.

Original languageEnglish (US)
Pages (from-to)208-219
Number of pages12
JournalJournal of Molecular Neuroscience
Issue number1-3
StatePublished - Nov 2008


  • Fear signals
  • Geomagnetic orientation
  • PAC1-R heterozygous-deficit (-/+) mice
  • Retrieval of memory
  • Visual orientation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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