TY - JOUR
T1 - Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention
AU - Zürcher, Nicole R.
AU - Rodriguez, Jesse S.
AU - Jenkins, Sue L.
AU - Keenan, Kate
AU - Bartlett, Thad Q.
AU - McDonald, Thomas J.
AU - Nathanielsz, Peter W.
AU - Nijland, Mark J.
PY - 2010/5
Y1 - 2010/5
N2 - The CANTAB (Cambridge Neuropsychological Test Automated Battery), a system developed for human neuropsychological testing, has previously been used to assess cognitive function in two species of nonhuman primates, common marmoset monkeys and rhesus macaques. We describe the application of the system to the juvenile baboon, a nonhuman primate species offering specific investigative advantages. Juvenile baboons were trained and tested on a progressive ratio task to assess motivation, simple discrimination and simple reversal tasks to assess associative learning, and intra- and extra-dimensional set-shifting tasks to assess selective attention and attentional set-shifting, respectively. Study subjects were 8 juvenile baboons (Papio sp.), 4 females and 4 males aged 3.0 ± 0.1 (mean + SEM) years and weight 8.2 ± 0.4 kg. All baboons were easily trained, readily learned the neuropsychological tests and exhibited a stable performance. Applying a method such as the CANTAB has significant implications for expanding on the translational utility of the baboon in studies of neurodevelopment.
AB - The CANTAB (Cambridge Neuropsychological Test Automated Battery), a system developed for human neuropsychological testing, has previously been used to assess cognitive function in two species of nonhuman primates, common marmoset monkeys and rhesus macaques. We describe the application of the system to the juvenile baboon, a nonhuman primate species offering specific investigative advantages. Juvenile baboons were trained and tested on a progressive ratio task to assess motivation, simple discrimination and simple reversal tasks to assess associative learning, and intra- and extra-dimensional set-shifting tasks to assess selective attention and attentional set-shifting, respectively. Study subjects were 8 juvenile baboons (Papio sp.), 4 females and 4 males aged 3.0 ± 0.1 (mean + SEM) years and weight 8.2 ± 0.4 kg. All baboons were easily trained, readily learned the neuropsychological tests and exhibited a stable performance. Applying a method such as the CANTAB has significant implications for expanding on the translational utility of the baboon in studies of neurodevelopment.
KW - Attention
KW - Learning
KW - Memory
KW - Operant conditioning
KW - Positive reinforcement
KW - Set-shifting
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U2 - 10.1016/j.jneumeth.2010.02.011
DO - 10.1016/j.jneumeth.2010.02.011
M3 - Article
C2 - 20170676
AN - SCOPUS:77951205521
VL - 188
SP - 219
EP - 225
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
IS - 2
ER -