Percutaneous hot saline injection therapy: Effectiveness in large hepatocellular carcinoma

Hyun Ki Yoon, Ho Young Song, Kyu Bo Sung, Young Hwa Chung, Yung Sang Lee, Dong Jin Suh, Seung Gyu Lee, Yong Ho Auh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


PURPOSE: To report on the efficacy of percutaneous hot saline injection therapy (PSIT) in the treatment of large hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Twenty-nine patients with 31 HCCs underwent PSIT. Physiologic saline was mixed with contrast medium and Lipiodol; this mixture was boiled and injected into the tumor. Mean tumor diameter was 7.0 cm. Initial regression rates were evaluated at 3-month interval with computed tomography (CT) and α-fetoprotein level measurement. Cumulative survival rates were calculated with the Kaplan-Meier method. Multivariate analysis using Cox's proportional hazard regression model was performed to determine the significant prognostic factors. RESULTS: Initial regression rate for all tumors at a 3-month interval was 42% (13 of 31 tumors) and the median survival was 10.0 months (range, 3.0-36.0 months). The significant prognostic factors were encapsulated tumors, tumors less than 10 cm in diameter, tumors with even saline dispersion, tumors with initial regression at 3-month follow-up, and TNM stage II or III rather than IV. CONCLUSION: PSIT is a feasible alternative treatment for a large HCC when transcatheter arterial chemoembolization is not feasible or has failed.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Issue number4
StatePublished - Apr 1999
Externally publishedYes


  • Liver neoplasms, CT
  • Liver neoplasms, therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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