Percutaneous coronary angioscopy with a new steerable microangioscope. Experimental and early clinical results

Stephen R. Ramee, Christopher J. White, Juan E. Mesa, Joseph P. Murgo, Thomas Doyle, Colleen McQueen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a new, steerable microangioscope for performing percutaneous coronary angioscopy. The angioscopic catheter is made of polyethylene, contains a distal balloon for occlusion of blood flow during imaging, fits through an 8 Fr percutaneous coronary angioplasty (PTCA) guiding catheter and is steerable by means of a guidewire. Initial feasibility was demonstrated in animal studies involving both peripheral and coronary arteries. Angioscopic findings in normal vessels included normal endothelial surface, collateral blood flow, and side branches. Angioscopy was also performed after balloon denudation of the arteries, laser-assisted balloon angioplasty, and stent implantation. In early human clinical trials we have performed percutaneous angioscopy in six patients undergoing percutaneous coronary angioplasty without complications. Findings in these patients include atherosclerotic plaque, thrombus, and dissection. This new device has great potential for use in the research, diagnosis, and treatment of coronary atherosclerosis.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsAbraham Katzir
PublisherPubl by Int Soc for Optical Engineering
Pages584-587
Number of pages4
ISBN (Print)0819402427
StatePublished - Dec 1 1990
EventProceedings of Optical Fibers in Medicine V - Los Angeles, CA, USA
Duration: Jan 14 1990Jan 19 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1201
ISSN (Print)0277-786X

Other

OtherProceedings of Optical Fibers in Medicine V
CityLos Angeles, CA, USA
Period1/14/901/19/90

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Ramee, S. R., White, C. J., Mesa, J. E., Murgo, J. P., Doyle, T., & McQueen, C. (1990). Percutaneous coronary angioscopy with a new steerable microangioscope. Experimental and early clinical results. In A. Katzir (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 584-587). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1201). Publ by Int Soc for Optical Engineering.