Peptides and growth regulatory factors in bone

G. R. Mundy

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


All bone is remodeled by bone resorbing (osteoclasts) and bone forming (osteoblasts) cells that are under the regulatory control of local factors generated in the bone cell microenvironment. These local factors are comprised of peptides and nonpeptides, including arachidonic acid metabolites such as prostaglandins of the E series and the leukotrienes. Most is known of the peptides that stimulate or inhibit osteoclastic bone resorption, but information is also now accumulating on the peptide growth factors that are incorporated into the bone matrix, released in an active form when bone is resorbed, and stimulate those cellular events that result in bone formation. In this article these control mechanisms are reviewed.

Original languageEnglish (US)
Pages (from-to)577-588
Number of pages12
JournalRheumatic Disease Clinics of North America
Issue number3
StatePublished - 1994

ASJC Scopus subject areas

  • Rheumatology


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