Pentobarbital enhances [3H]diazepam binding to soluble receptors at the benzodiazepine-GABA-receptor-ionophore complex

William C. Davis; Maharaj K. Ticku

doi:10.1016/0304-3940(81)90042-2

Pentobarbital enhances [³H]diazepam binding to soluble receptors at the benzodiazepine-GABA-receptor-ionophore complex

William C. Davis, Maharaj K. Ticku

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Pentobarbital enhances [³H]diazepam binding to soluble receptors in a dose-dependent and saturable manner. Half-maximal enhancement occurred at 110 μM pentobarbital. This enhancement was due to an increase in the affinity of diazepam to its receptor sites. Pentobarbital enhancement was blocked by pictrotoxinin and bicuculline. These results are similar to those reported for membranes and suggest that various components of the benzodiazepine-GABA-receptor-ionophore complex are intimately associated.

Original language	English (US)
Pages (from-to)	209-213
Number of pages	5
Journal	Neuroscience Letters
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(81)90042-2
State	Published - May 6 1981

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(81)90042-2

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N2 - Pentobarbital enhances [3H]diazepam binding to soluble receptors in a dose-dependent and saturable manner. Half-maximal enhancement occurred at 110 μM pentobarbital. This enhancement was due to an increase in the affinity of diazepam to its receptor sites. Pentobarbital enhancement was blocked by pictrotoxinin and bicuculline. These results are similar to those reported for membranes and suggest that various components of the benzodiazepine-GABA-receptor-ionophore complex are intimately associated.

AB - Pentobarbital enhances [3H]diazepam binding to soluble receptors in a dose-dependent and saturable manner. Half-maximal enhancement occurred at 110 μM pentobarbital. This enhancement was due to an increase in the affinity of diazepam to its receptor sites. Pentobarbital enhancement was blocked by pictrotoxinin and bicuculline. These results are similar to those reported for membranes and suggest that various components of the benzodiazepine-GABA-receptor-ionophore complex are intimately associated.

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Pentobarbital enhances [³H]diazepam binding to soluble receptors at the benzodiazepine-GABA-receptor-ionophore complex

Abstract

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