Pentobarbital enhances [3H]diazepam binding to soluble receptors at the benzodiazepine-GABA-receptor-ionophore complex

William C. Davis, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Pentobarbital enhances [3H]diazepam binding to soluble receptors in a dose-dependent and saturable manner. Half-maximal enhancement occurred at 110 μM pentobarbital. This enhancement was due to an increase in the affinity of diazepam to its receptor sites. Pentobarbital enhancement was blocked by pictrotoxinin and bicuculline. These results are similar to those reported for membranes and suggest that various components of the benzodiazepine-GABA-receptor-ionophore complex are intimately associated.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalNeuroscience Letters
Volume23
Issue number2
DOIs
StatePublished - May 6 1981

ASJC Scopus subject areas

  • Neuroscience(all)

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