Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis

Michail S. Lionakis, Georgios Chamilos, Russell E. Lewis, Nathan P. Wiederhold, Issam I. Raad, George Samonis, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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