Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis

Michail S. Lionakis; Georgios Chamilos; Russell E. Lewis; Nathan P. Wiederhold; Issam I. Raad; George Samonis; Dimitrios P. Kontoyiannis

doi:10.1128/AAC.50.1.294-297.2006

Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis

Michail S. Lionakis, Georgios Chamilos, Russell E. Lewis, Nathan P. Wiederhold, Issam I. Raad, George Samonis, Dimitrios P. Kontoyiannis

Pathology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

Original language	English (US)
Pages (from-to)	294-297
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	1
DOIs	https://doi.org/10.1128/AAC.50.1.294-297.2006
State	Published - Jan 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis. / Lionakis, Michail S.; Chamilos, Georgios; Lewis, Russell E.; Wiederhold, Nathan P.; Raad, Issam I.; Samonis, George; Kontoyiannis, Dimitrios P.

In: Antimicrobial agents and chemotherapy, Vol. 50, No. 1, 01.2006, p. 294-297.

Research output: Contribution to journal › Article › peer-review

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