TY - JOUR
T1 - Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis
AU - Lionakis, Michail S.
AU - Chamilos, Georgios
AU - Lewis, Russell E.
AU - Wiederhold, Nathan P.
AU - Raad, Issam I.
AU - Samonis, George
AU - Kontoyiannis, Dimitrios P.
PY - 2006/1
Y1 - 2006/1
N2 - We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
AB - We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
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U2 - 10.1128/AAC.50.1.294-297.2006
DO - 10.1128/AAC.50.1.294-297.2006
M3 - Article
C2 - 16377700
AN - SCOPUS:29944447034
VL - 50
SP - 294
EP - 297
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -