Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species

Samar S.A. Mourshid; Jihan M. Badr; April L. Risinger; Susan L. Mooberry; Diaa T.A. Youssef

doi:10.1515/znc-2015-0242

Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species

Samar S.A. Mourshid, Jihan M. Badr, April L. Risinger, Susan L. Mooberry, Diaa T.A. Youssef

Pharmacology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Two new antimicrobial fatty acid esters, penicilloitins A and B (1 and 2), along with α-cyclopiazonic acid (3), tryptamine (4) and indole-3-carbaldehyde (5), were isolated from mycelial extracts and the culture broth of a marine endophytic Penicillium species and their structures established by spectroscopic techniques including 1D (¹H NMR and ¹³C NMR) and 2D NMR (COSY, multiplicity-edited HSQC, and HMBC) as well as HRESIMS. Of these compounds, 1, 3 and 4 displayed modest antimicrobial activity.

Original language	English (US)
Pages (from-to)	387-392
Number of pages	6
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	71
Issue number	11-12
DOIs	https://doi.org/10.1515/znc-2015-0242
State	Published - Nov 1 2016

Keywords

Didemnum
Penicillium
antimicrobial
fatty acid esters

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1515/znc-2015-0242

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Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species. / Mourshid, Samar S.A.; Badr, Jihan M.; Risinger, April L.; Mooberry, Susan L.; Youssef, Diaa T.A.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 71, No. 11-12, 01.11.2016, p. 387-392.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two new antimicrobial fatty acid esters, penicilloitins A and B (1 and 2), along with α-cyclopiazonic acid (3), tryptamine (4) and indole-3-carbaldehyde (5), were isolated from mycelial extracts and the culture broth of a marine endophytic Penicillium species and their structures established by spectroscopic techniques including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, multiplicity-edited HSQC, and HMBC) as well as HRESIMS. Of these compounds, 1, 3 and 4 displayed modest antimicrobial activity.",

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note = "Funding Information: This project was supported by the NSTIP strategic technologies program in the Kingdom of Saudi Arabia, project no. 11-BIO1556-03. The authors also gratefully acknowledge the Science and Technology Unit, King Abdulaziz University, for technical support. Publisher Copyright: {\textcopyright} 2016 Walter de Gruyter GmbH, Berlin/Boston.",

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AU - Risinger, April L.

AU - Mooberry, Susan L.

AU - Youssef, Diaa T.A.

N1 - Funding Information: This project was supported by the NSTIP strategic technologies program in the Kingdom of Saudi Arabia, project no. 11-BIO1556-03. The authors also gratefully acknowledge the Science and Technology Unit, King Abdulaziz University, for technical support. Publisher Copyright: © 2016 Walter de Gruyter GmbH, Berlin/Boston.

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AB - Two new antimicrobial fatty acid esters, penicilloitins A and B (1 and 2), along with α-cyclopiazonic acid (3), tryptamine (4) and indole-3-carbaldehyde (5), were isolated from mycelial extracts and the culture broth of a marine endophytic Penicillium species and their structures established by spectroscopic techniques including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, multiplicity-edited HSQC, and HMBC) as well as HRESIMS. Of these compounds, 1, 3 and 4 displayed modest antimicrobial activity.

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Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species

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Keywords

ASJC Scopus subject areas

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