Pedigree analysis of HDL cholesterol concentration in baboons on two diets

J. W. MacCluer, C. M. Kammerer, J. Blangero, B. Dyke, G. E. Mott, J. L. VandeBerg, H. C. McGill

    Research output: Contribution to journalArticlepeer-review

    24 Scopus citations


    Using complex segregation analysis, we examined the effects of genetic factors and diet on serum concentrations of high-density-lipoprotein cholesterol (HDL-C) in baboons. In analyses of 710 baboons in 23 sire families, we found evidence for a major gene as well as a polygenic contribution to HDL-C concentration in baboons fed a basal (chow) diet and also in the same animals after challenge with a high-cholesterol, saturated-fat diet. There was evidence for a polygenic contribution to the change in HDL-C concentration in response to the dietary challenge, but there was no evidence for a major gene effect.

    Original languageEnglish (US)
    Pages (from-to)401-413
    Number of pages13
    JournalAmerican Journal of Human Genetics
    Issue number4
    StatePublished - 1988

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)


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