Pedigree analysis of HDL cholesterol concentration in baboons on two diets

J. W. MacCluer, C. M. Kammerer, John C Blangero, B. Dyke, G. E. Mott, John L VandeBerg, H. C. McGill

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Using complex segregation analysis, we examined the effects of genetic factors and diet on serum concentrations of high-density-lipoprotein cholesterol (HDL-C) in baboons. In analyses of 710 baboons in 23 sire families, we found evidence for a major gene as well as a polygenic contribution to HDL-C concentration in baboons fed a basal (chow) diet and also in the same animals after challenge with a high-cholesterol, saturated-fat diet. There was evidence for a polygenic contribution to the change in HDL-C concentration in response to the dietary challenge, but there was no evidence for a major gene effect.

Original languageEnglish (US)
Pages (from-to)401-413
Number of pages13
JournalAmerican Journal of Human Genetics
Issue number4
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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