Pediatric oncology

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Intensive use of cytotoxic agents in multimodality therapeutic regimens has resulted in almost 80% five-year disease-free survival and cure in the majority of childhood cancer patients. However, such success has come at the expense of severe acute or delayed toxicities and an increased occurrence of secondary cancers. With an increasing understanding of the genetic changes that underlie transformation in childhood cancer, rational approaches using agents that target these transforming events are being developed. Current and future strategies in developing tumor-selective therapy using inhibitors of signaling pathways dysregulated in leukemias (FLT3, NOTCH1) and solid/brain tumors (ErbB1-4, IGF-IR, PTCH1), and the challenges in developing less toxic, but equally effective treatments in pediatric oncology are presented.

Original languageEnglish (US)
Pages (from-to)424-432
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume11
Issue number4
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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