Pediatric en bloc kidney transplantation to adult recipients: More than suboptimal?

Suverta Bhayana, Yong Fang Kuo, Pankaj Madan, Sreedhar Mandaym, Philip G. Thomas, Jacqueline A. Lappin, James C. Rice, Kanae Ishihara

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background: To optimize available organs, kidneys from young donors traditionally beleived to be suboptimal are transplanted to adults. The purpose of this study is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other deceased donor transplants in adult recipients. Methods: We analyzed United Network of Organ Sharing/STAR data on primary deceased donor kidney transplants to adult recipients (1988-2006). EBK (age younger than 5 years, n=1696) was compared with solitary pediatric (SP; age younger than 5 years) kidneys (n=1502), and matched standard adult donors (age 18-59 years, n=9594) and expanded criteria donor (ECD; n=6396). The adjusted GS was obtained using Cox proportional hazard model and hazard ratios were calculated. Results: EBK had lowest acute rejection rates (6.0%) but similar to standard adult transplants (6.3%), and lower than SP and ECD (9.0% and 8.2%; P<0.0001). Delayed graft function rates were lowest in EBK (17.9%), highest in ECD (34.8%; P<0.0001), and similar among SP and standard adult transplants (24.4% and 24.2%). The estimated glomerular filtration rate (eGFR) was best in EBK and worst in ECD (P<0.0001). The eGFR of EBK and SP transplants continuously improved but the eGFR of standard adult and ECD declined. Graft loss was higher in EBK and SP transplants than adult donor transplants during the first 6 months. Despite the highest thrombosis rates in EBK (5.0%) (SP, 3.3%; standard adult, 1.8%; ECD, 2.0%, P<0.0001), GS of EBK became similar to standard adult donor transplants by 5 years and best at 10 years posttransplant (64.0%) and worst in ECD (39.6%; P<0.0001). Conclusion: EBK had the best long-term outcomes among deceased donor transplants and offer unique options for adult kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalTransplantation
Volume90
Issue number3
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

Keywords

  • Deceased donor
  • En bloc
  • GFR
  • Graft survival
  • Kidney transplantation
  • Pediatric donor
  • UNOS

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Bhayana, S., Kuo, Y. F., Madan, P., Mandaym, S., Thomas, P. G., Lappin, J. A., Rice, J. C., & Ishihara, K. (2010). Pediatric en bloc kidney transplantation to adult recipients: More than suboptimal? Transplantation, 90(3), 248-254. https://doi.org/10.1097/TP.0b013e3181e641f8