PD-1 inhibition achieves a complete metabolic response in a patient with malignant peripheral nerve sheath tumor

Lisa E. Davis, Lauren A. Nicholls, Hani M. Babiker, Joy Liau, Daruka Mahadevan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

High-grade malignant peripheral nerve sheath tumors (MPNST) have a poor prognosis with limited responsiveness to systemic therapy. We document a case of a complete metabolic response to pembrolizumab monotherapy in metastatic disease. Tumor molecular profiling identified programmed-death ligand-1 (PD-L1) positivity. This characteristic provided a rationale for immune-checkpoint therapy. Treatment with pembrolizumab resulted in a complete metabolic response after four cycles of therapy. Patients with PD-L1–positive, metastatic MPNST may be candidates for immune-checkpoint therapy, which may produce a durable complete remission. Future study of anti–PD-1/PD-L1 therapy is warranted.

Original languageEnglish (US)
Pages (from-to)1396-1400
Number of pages5
JournalCancer Immunology Research
Volume7
Issue number9
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Immunology
  • Cancer Research

Fingerprint Dive into the research topics of 'PD-1 inhibition achieves a complete metabolic response in a patient with malignant peripheral nerve sheath tumor'. Together they form a unique fingerprint.

Cite this