Patterns of Infection: Unwanted Guests-Quick Visits and Extended Stays

Neal Nathanson, Francisco González-Scarano

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The preceding chapters describe essential aspects of viral pathogenesis, including virus-cell interactions; viral spread within a host; and intrinsic, innate, and adaptive immune responses. This chapter extends the theme and addresses diverse patterns of viral infections that are determined by both the virus and the host. Thus, virulence or susceptibility depends upon the specific virus-host combination. This is particularly true in the case of persistent infections, which involve a delicate balance between virus and host. We will focus first on virus virulence and host susceptibility, and then turn to the complex variables that govern persistent infections. Chapters 4-6, on innate, adaptive, and aberrant immunity, and Chapters 11-15, on systems biology approaches, also provide important insights into the patterns of infection.

Original languageEnglish (US)
Title of host publicationViral Pathogenesis
Subtitle of host publicationFrom Basics to Systems Biology: Third Edition
PublisherElsevier Inc.
Number of pages14
ISBN (Print)9780128009642
StatePublished - 2016


  • Central nervous system
  • Neurovirulence
  • Persistence
  • Viral pathogenesis
  • Viroceptors and virokines
  • Virulence
  • Virus-cell interactions

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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