Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

Janine Mikolajczak, Hanna Zimmermann, Ahmad Kheirkhah, Ella Maria Kadas, Timm Oberwahrenbrock, Rodrigo Muller, Aiai Ren, Joseph Kuchling, Holger Dietze, Harald Prüss, Friedemann Paul, Pedram Hamrah, Alexander U. Brandt

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Background: Many studies in multiple sclerosis (MS) have investigated the retina. Little, however, is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response to environmental stimuli. Objective: This study aims to investigate the effect of MS on corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM). Methods: We measured the corneal nerve fibre and dendritic cell density in 26 MS patients and matched healthy controls using a Heidelberg Retina Tomograph with cornea module. Disease severity was assessed with the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale, visual acuity and retinal optical coherence tomography. Results: We observed significant reduction in total corneal nerve fibre density in MS patients compared to controls. Dendritic cell density was similar in both groups. Reduced total nerve fibre density was associated with worse clinical severity but not with previous clinical trigeminal symptoms, retinal neuro-axonal damage, visual acuity or disease duration. Conclusion: Corneal nerve fibre density is a promising new imaging marker for the assessment of disease severity in MS and should be investigated further.

Original languageEnglish (US)
Pages (from-to)1847-1853
Number of pages7
JournalMultiple Sclerosis
Volume23
Issue number14
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Keywords

  • Multiple sclerosis
  • cornea
  • peripheral nerves
  • retina
  • subbasal nerve plexus
  • trigeminal neuralgia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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