TY - JOUR
T1 - Patient characteristics associated with buprenorphine/naloxone treatment outcome for prescription opioid dependence
T2 - Results from a multisite study
AU - Dreifuss, Jessica A.
AU - Griffin, Margaret L.
AU - Frost, Katherine
AU - Fitzmaurice, Garrett M.
AU - Potter, Jennifer Sharpe
AU - Fiellin, David A.
AU - Selzer, Jeffrey
AU - Hatch-Maillette, Mary
AU - Sonne, Susan C.
AU - Weiss, Roger D.
N1 - Funding Information:
This work was supported by a series of grants from NIDA as part of the Cooperative Agreement on the Clinical Trials Network (CTN): grants U10 DA015831 , U10 DA020024 , U10 DA13035 , U10 DA013714 , and U10 DA013727 ; NIDA grants K24 DA022288 , K23 DA022297 , R01 DA019511 , R01 DA020576 , R01 DA025991 , and RC1 DA028245 ; and NIAAA grant U01 AA020795 . NIDA and NIAAA had no further role in study design; in the collection, analysis and interpretation of data; or in the writing of the report. The NIDA CTN Publication Committee has reviewed a draft of this manuscript and approved it for submission for publication.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Background: Prescription opioid dependence is a growing problem, but little research exists on its treatment, including patient characteristics that predict treatment outcome. Methods: A secondary analysis of data from a large multisite, randomized clinical trial, the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study (POATS) was undertaken to examine baseline patient characteristics (. N=. 360) associated with success during 12-week buprenorphine/naloxone treatment for prescription opioid dependence. Baseline predictor variables included self-reported demographic and opioid use history information, diagnoses assessed via the Composite International Diagnostic Interview, and historical opioid use and related information from the Pain And Opiate Analgesic Use History. Results: In bivariate analyses, pre-treatment characteristics associated with successful opioid use outcome included older age, past-year or lifetime diagnosis of major depressive disorder, initially obtaining opioids with a medical prescription to relieve pain, having only used opioids by swallowing or sublingual administration, never having used heroin, using an opioid other than extended-release oxycodone most frequently, and no prior opioid dependence treatment. In multivariate analysis, age, lifetime major depressive disorder, having only used opioids by swallowing or sublingual administration, and receiving no prior opioid dependence treatment remained as significant predictors of successful outcome. Conclusions: This is the first study to examine characteristics associated with treatment outcome in patients dependent exclusively on prescription opioids. Characteristics associated with successful outcome after 12 weeks of buprenorphine/naloxone treatment include some that have previously been found to predict heroin-dependent patients' response to methadone treatment and some specific to prescription opioid-dependent patients receiving buprenorphine/naloxone.
AB - Background: Prescription opioid dependence is a growing problem, but little research exists on its treatment, including patient characteristics that predict treatment outcome. Methods: A secondary analysis of data from a large multisite, randomized clinical trial, the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study (POATS) was undertaken to examine baseline patient characteristics (. N=. 360) associated with success during 12-week buprenorphine/naloxone treatment for prescription opioid dependence. Baseline predictor variables included self-reported demographic and opioid use history information, diagnoses assessed via the Composite International Diagnostic Interview, and historical opioid use and related information from the Pain And Opiate Analgesic Use History. Results: In bivariate analyses, pre-treatment characteristics associated with successful opioid use outcome included older age, past-year or lifetime diagnosis of major depressive disorder, initially obtaining opioids with a medical prescription to relieve pain, having only used opioids by swallowing or sublingual administration, never having used heroin, using an opioid other than extended-release oxycodone most frequently, and no prior opioid dependence treatment. In multivariate analysis, age, lifetime major depressive disorder, having only used opioids by swallowing or sublingual administration, and receiving no prior opioid dependence treatment remained as significant predictors of successful outcome. Conclusions: This is the first study to examine characteristics associated with treatment outcome in patients dependent exclusively on prescription opioids. Characteristics associated with successful outcome after 12 weeks of buprenorphine/naloxone treatment include some that have previously been found to predict heroin-dependent patients' response to methadone treatment and some specific to prescription opioid-dependent patients receiving buprenorphine/naloxone.
KW - Buprenorphine
KW - Drug dependence
KW - Heroin
KW - Opioid analgesics
KW - Predictors
KW - Prescription opioids
KW - Substance abuse
KW - Treatment outcome
UR - https://www.scopus.com/pages/publications/84878576685
UR - https://www.scopus.com/pages/publications/84878576685#tab=citedBy
U2 - 10.1016/j.drugalcdep.2012.12.010
DO - 10.1016/j.drugalcdep.2012.12.010
M3 - Article
C2 - 23333292
AN - SCOPUS:84878576685
SN - 0376-8716
VL - 131
SP - 112
EP - 118
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 1-3
ER -