Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

ChunYan Y. Li, WeiZhuo Z. Wang, Xiong Guo, Feng Zhang, WeiJuan J. Ma, YinGang G. Zhang, YouFen F. Li, Yidong Bai, Mikko J. Lammi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

Original languageEnglish (US)
Pages (from-to)1057-1063
Number of pages7
JournalScience China Life Sciences
Volume55
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Kashin-Beck Disease
Mitochondria
osteoarthritis
Cartilage
mitochondrion
cartilage
Osteoarthritis
China
mitochondria
Gene expression
gene expression
Genes
Gene Expression
oxidative phosphorylation
gene
Oxidative Phosphorylation
apoptosis
Articular Cartilage
Pyruvic Acid
Transcriptome

Keywords

  • IPA analysis
  • Kashin-Beck disease
  • microarray
  • mitochondrial dysfunction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Li, C. Y., Wang, W. Z., Guo, X., Zhang, F., Ma, W. J., Zhang, Y. G., ... Lammi, M. J. (2012). Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. Science China Life Sciences, 55(12), 1057-1063. https://doi.org/10.1007/s11427-012-4418-4

Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. / Li, ChunYan Y.; Wang, WeiZhuo Z.; Guo, Xiong; Zhang, Feng; Ma, WeiJuan J.; Zhang, YinGang G.; Li, YouFen F.; Bai, Yidong; Lammi, Mikko J.

In: Science China Life Sciences, Vol. 55, No. 12, 12.2012, p. 1057-1063.

Research output: Contribution to journalArticle

Li, ChunYan Y. ; Wang, WeiZhuo Z. ; Guo, Xiong ; Zhang, Feng ; Ma, WeiJuan J. ; Zhang, YinGang G. ; Li, YouFen F. ; Bai, Yidong ; Lammi, Mikko J. / Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. In: Science China Life Sciences. 2012 ; Vol. 55, No. 12. pp. 1057-1063.
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