Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

Chun Yan Li, Wei Zhuo Wang, Xiong Guo, Feng Zhang, Wei Juan Ma, Yin Gang Zhang, You Fen Li, Yi Dong Bai, Mikko J. Lammi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

Original languageEnglish (US)
Pages (from-to)1057-1063
Number of pages7
JournalScience China Life Sciences
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2012

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Keywords

  • IPA analysis
  • Kashin-Beck disease
  • microarray
  • mitochondrial dysfunction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Li, C. Y., Wang, W. Z., Guo, X., Zhang, F., Ma, W. J., Zhang, Y. G., Li, Y. F., Bai, Y. D., & Lammi, M. J. (2012). Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. Science China Life Sciences, 55(12), 1057-1063. https://doi.org/10.1007/s11427-012-4418-4