Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

Chun Yan Li; Wei Zhuo Wang; Xiong Guo; Feng Zhang; Wei Juan Ma; Yin Gang Zhang; You Fen Li; Yi Dong Bai; Mikko J. Lammi

doi:10.1007/s11427-012-4418-4

Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

Chun Yan Li, Wei Zhuo Wang, Xiong Guo, Feng Zhang, Wei Juan Ma, Yin Gang Zhang, You Fen Li, Yi Dong Bai, Mikko J. Lammi

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

Original language	English (US)
Pages (from-to)	1057-1063
Number of pages	7
Journal	Science China Life Sciences
Volume	55
Issue number	12
DOIs	https://doi.org/10.1007/s11427-012-4418-4
State	Published - Dec 2012

Keywords

IPA analysis
Kashin-Beck disease
microarray
mitochondrial dysfunction

ASJC Scopus subject areas

General Environmental Science
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1007/s11427-012-4418-4

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title = "Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China",

abstract = "In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.",

keywords = "IPA analysis, Kashin-Beck disease, microarray, mitochondrial dysfunction",

author = "Li, {Chun Yan} and Wang, {Wei Zhuo} and Xiong Guo and Feng Zhang and Ma, {Wei Juan} and Zhang, {Yin Gang} and Li, {You Fen} and Bai, {Yi Dong} and Lammi, {Mikko J.}",

note = "Funding Information: We thank the orthopedic surgeons and nursing staff of the Department of Orthopedics or Trauma in the Xi{\textquoteright}an Red Cross Hospital, the Second Affiliated Hospital of Xi{\textquoteright}an Jiaotong University and Shaanxi Endemic Disease Hospital for support and cooperation in the collection of cartilage specimens. This work was supported in part by the National Natural Science Foundation of China (Grant No. 30972556), the Key Scientific and Technological Innovation Special Projects of Shaanxi “13115” of China (Grant No. 2009ZDKG-79) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090201110049).",

year = "2012",

month = dec,

doi = "10.1007/s11427-012-4418-4",

language = "English (US)",

volume = "55",

pages = "1057--1063",

journal = "Science China Life Sciences",

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T1 - Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

AU - Li, Chun Yan

AU - Wang, Wei Zhuo

AU - Guo, Xiong

AU - Zhang, Feng

AU - Ma, Wei Juan

AU - Zhang, Yin Gang

AU - Li, You Fen

AU - Bai, Yi Dong

AU - Lammi, Mikko J.

N1 - Funding Information: We thank the orthopedic surgeons and nursing staff of the Department of Orthopedics or Trauma in the Xi’an Red Cross Hospital, the Second Affiliated Hospital of Xi’an Jiaotong University and Shaanxi Endemic Disease Hospital for support and cooperation in the collection of cartilage specimens. This work was supported in part by the National Natural Science Foundation of China (Grant No. 30972556), the Key Scientific and Technological Innovation Special Projects of Shaanxi “13115” of China (Grant No. 2009ZDKG-79) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090201110049).

PY - 2012/12

Y1 - 2012/12

N2 - In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

AB - In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

KW - IPA analysis

KW - Kashin-Beck disease

KW - microarray

KW - mitochondrial dysfunction

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Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

Abstract

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