Pathways mediating low shear stress-induced vascular endothelial gene activation

Eugene A. Sprague; Sumathy Mohan; Lisa Ballou; Robert M. Nerem

Pathways mediating low shear stress-induced vascular endothelial gene activation

Eugene A. Sprague, Sumathy Mohan, Lisa Ballou, Robert M. Nerem

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	655-656
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - 1999
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

General Engineering

Cite this

@inproceedings{873f8c49c52744758a0706ded8f48ca3,

title = "Pathways mediating low shear stress-induced vascular endothelial gene activation",

abstract = "An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.",

author = "Sprague, {Eugene A.} and Sumathy Mohan and Lisa Ballou and Nerem, {Robert M.}",

year = "1999",

language = "English (US)",

isbn = "0791816117",

volume = "42",

pages = "655--656",

booktitle = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

publisher = "ASME",

note = "1999 Bioengineering Conference ; Conference date: 16-06-1999 Through 20-06-1999",

}

TY - GEN

T1 - Pathways mediating low shear stress-induced vascular endothelial gene activation

AU - Sprague, Eugene A.

AU - Mohan, Sumathy

AU - Ballou, Lisa

AU - Nerem, Robert M.

PY - 1999

Y1 - 1999

N2 - An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.

AB - An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.

UR - http://www.scopus.com/inward/record.url?scp=0033298690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033298690&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033298690

SN - 0791816117

VL - 42

SP - 655

EP - 656

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

T2 - 1999 Bioengineering Conference

Y2 - 16 June 1999 through 20 June 1999

ER -

Pathways mediating low shear stress-induced vascular endothelial gene activation

Abstract

Other

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this