Pathways mediating low shear stress-induced vascular endothelial gene activation

Eugene A. Sprague, Sumathy Mohan, Lisa Ballou, Robert M. Nerem

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages655-656
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

ASJC Scopus subject areas

  • Engineering(all)

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