Pathways mediating low shear stress-induced vascular endothelial gene activation

Eugene A. Sprague, Sumathy Mohan, Lisa Ballou, Robert M. Nerem

Research output: Chapter in Book/Report/Conference proceedingConference contribution


An account is given on new data indicating that low shear induced MCP-1 and VCAM-1 gene activation may involve interaction of multiple signal transduction pathways, including the NF-kB and mitogen-activated protein kinase (MAPK) systems. The data indicate that NF-kB plays a key role in the endothelial response to chronic LS flow conditions.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Other1999 Bioengineering Conference
CityBig Sky, MT, USA

ASJC Scopus subject areas

  • General Engineering


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