Pathophysiology, research challenges, and clinical management of smoke inhalation injury

Perenlei Enkhbaatar, Basil A. Pruitt, Oscar Suman, Ronald Mlcak, Steven E. Wolf, Hiroyuki Sakurai, David N. Herndon

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.

Original languageEnglish (US)
Pages (from-to)1437-1446
Number of pages10
JournalThe Lancet
Volume388
Issue number10052
DOIs
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Medicine(all)

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    Enkhbaatar, P., Pruitt, B. A., Suman, O., Mlcak, R., Wolf, S. E., Sakurai, H., & Herndon, D. N. (2016). Pathophysiology, research challenges, and clinical management of smoke inhalation injury. The Lancet, 388(10052), 1437-1446. https://doi.org/10.1016/S0140-6736(16)31458-1