Pathophysiology of vein graft failure: A review

Mark G. Davies, Per Otto Hagen

Research output: Contribution to journalReview articlepeer-review

250 Scopus citations


Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.

Original languageEnglish (US)
Pages (from-to)7-18
Number of pages12
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number1
StatePublished - Jan 1995
Externally publishedYes


  • Atherosclerosis
  • Failure
  • Intimal hyperplasia
  • Smooth muscle cell endothelium
  • Vein
  • Vein graft

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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