Pathophysiology of myeloma bone disease

Babatunde O. Oyajobi, Gregory R. Mundy

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Multiple myeloma is characterized by a unique form of destructive bone disease, which occurs in the majority of patients. The bone destruction, which is progressive, is responsible for the most prominent and distressing clinical features of this disease, namely intractable bone pain, fractures occurring either spontaneously or following trivial injury, and hypercalcemia with its attendant symptoms and signs. Although myeloma is a disease with protean features resulting from the effects of the disease on multiple organ systems, perhaps its most important clinical manifestation, and certainly the one that most often heralds the onset of the disease, is its effects on the skeleton. This chapter will focus on the pathophysiology of the bone lesions in myeloma.

Original languageEnglish (US)
Title of host publicationMultiple Myeloma and Related Disorders
PublisherCRC Press
Pages74-88
Number of pages15
ISBN (Electronic)9781444114140
ISBN (Print)9780340810101
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

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    Oyajobi, B. O., & Mundy, G. R. (2004). Pathophysiology of myeloma bone disease. In Multiple Myeloma and Related Disorders (pp. 74-88). CRC Press.