Pathophysiology of Contrast-Induced Acute Kidney Injury

Shweta Bansal, Rahul N. Patel

Research output: Contribution to journalReview article

Abstract

Passing contrast media through the renal vascular bed leads to vasoconstriction. The perfusion decrease leads to ischemia of tubular cells. Through ischemia and direct toxicity to renal tubular cells, reactive oxygen species formation is increased, enhancing the effect of vasoconstrictive mediators and decreasing the bioavailability of vasodilative mediators. Reactive oxygen species formation leads to oxidative damage to tubular cells. These interacting pathways lead to tubular necrosis. In the pathophysiology of contrast-induced acute kidney injury, low osmolar and iso-osmolar agents have theoretic advantages and disadvantages; however, clinically the difference in incidence of contrast-induced acute kidney injury has not changed.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalInterventional Cardiology Clinics
Volume9
Issue number3
DOIs
StatePublished - Jul 2020

Keywords

  • Contrast media adverse effects
  • Contrast media toxicity
  • Contrast-associated acute kidney injury
  • Contrast-induced acute kidney injury
  • Contrast-induced nephropathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Pathophysiology of Contrast-Induced Acute Kidney Injury'. Together they form a unique fingerprint.

  • Cite this