Pathology of Bronchopulmonary Dysplasia

Jacqueline J. Coalson

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

Over the past three decades, advances in prenatal and neonatal intensive care have contributed to marked improvements in survival rates for extremely immature infants born during the canalicular phase of lung development at 24 to 26 weeks, a time when alveolar and distal vascular development is rapidly occurring. The histopathological lesions of severe airway injury and alternating sites of overinflation and fibrosis in "old" BPD have been replaced in "new" BPD with the pathologic changes of large, simplified alveolar structures, a dysmorphic capillary configuration, and variable interstitial cellularity and/or fibroproliferation. Airway and vascular lesions, when present, tend to be present in infants, who over time develop more severe disease. The concept that "new" BPD results in an arrest in alveolization should be modified to that of an impairment in alveolization as evidence shows that short ventilatory times and/or the use of nCPAP allow continued alveolar formation.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalSeminars in Perinatology
Volume30
Issue number4
DOIs
StatePublished - Aug 2006

Fingerprint

Bronchopulmonary Dysplasia
Pathology
Blood Vessels
Neonatal Intensive Care
Fibrosis
Lung
Wounds and Injuries

Keywords

  • alveolization
  • animal model
  • BPD
  • lung pathology
  • nCPAP
  • vascularization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pathology of Bronchopulmonary Dysplasia. / Coalson, Jacqueline J.

In: Seminars in Perinatology, Vol. 30, No. 4, 08.2006, p. 179-184.

Research output: Contribution to journalArticle

Coalson, Jacqueline J. / Pathology of Bronchopulmonary Dysplasia. In: Seminars in Perinatology. 2006 ; Vol. 30, No. 4. pp. 179-184.
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