Pathology and pathogenesis of nephrotoxic membrane damage

D. W. Schwertz; D. A. Troyer; J. I. Kreisberg; Manjeri A Venkatachalam

Pathology and pathogenesis of nephrotoxic membrane damage

D. W. Schwertz, D. A. Troyer, J. I. Kreisberg, Manjeri A Venkatachalam

Department of Pathology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

These findings demonstrate that HgCl₂ and gentamicin-elicited alterations in LLC-PK₁ cell membrane ultrastructure are similar to membrane changes observed in whole animal models. These ultrastructural alterations in cell membranes are associated with altered phosphoglyceride metabolism. Since phospholipids are intimately associated with maintenance of cell membrane integrity and therefore cellular homeostasis, it is conceivable that nephrotoxin-induced changes in renal membrane phospholipids may play a critical role in acute toxic renal failure.

Original language	English (US)
Pages (from-to)	63-71
Number of pages	9
Journal	Transplantation Proceedings
Volume	17
Issue number	4 SUPPL. 1
State	Published - 1985

ASJC Scopus subject areas

Surgery
Transplantation

Cite this

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title = "Pathology and pathogenesis of nephrotoxic membrane damage",

abstract = "These findings demonstrate that HgCl2 and gentamicin-elicited alterations in LLC-PK1 cell membrane ultrastructure are similar to membrane changes observed in whole animal models. These ultrastructural alterations in cell membranes are associated with altered phosphoglyceride metabolism. Since phospholipids are intimately associated with maintenance of cell membrane integrity and therefore cellular homeostasis, it is conceivable that nephrotoxin-induced changes in renal membrane phospholipids may play a critical role in acute toxic renal failure.",

author = "Schwertz, {D. W.} and Troyer, {D. A.} and Kreisberg, {J. I.} and Venkatachalam, {Manjeri A}",

year = "1985",

language = "English (US)",

volume = "17",

pages = "63--71",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier Inc.",

number = "4 SUPPL. 1",

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TY - JOUR

T1 - Pathology and pathogenesis of nephrotoxic membrane damage

AU - Schwertz, D. W.

AU - Troyer, D. A.

AU - Kreisberg, J. I.

AU - Venkatachalam, Manjeri A

PY - 1985

Y1 - 1985

N2 - These findings demonstrate that HgCl2 and gentamicin-elicited alterations in LLC-PK1 cell membrane ultrastructure are similar to membrane changes observed in whole animal models. These ultrastructural alterations in cell membranes are associated with altered phosphoglyceride metabolism. Since phospholipids are intimately associated with maintenance of cell membrane integrity and therefore cellular homeostasis, it is conceivable that nephrotoxin-induced changes in renal membrane phospholipids may play a critical role in acute toxic renal failure.

AB - These findings demonstrate that HgCl2 and gentamicin-elicited alterations in LLC-PK1 cell membrane ultrastructure are similar to membrane changes observed in whole animal models. These ultrastructural alterations in cell membranes are associated with altered phosphoglyceride metabolism. Since phospholipids are intimately associated with maintenance of cell membrane integrity and therefore cellular homeostasis, it is conceivable that nephrotoxin-induced changes in renal membrane phospholipids may play a critical role in acute toxic renal failure.

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M3 - Review article

C2 - 3895672

AN - SCOPUS:0022403149

SN - 0041-1345

VL - 17

SP - 63

EP - 71

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 4 SUPPL. 1

ER -

Pathology and pathogenesis of nephrotoxic membrane damage

Abstract

ASJC Scopus subject areas

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