Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao; Chelsea Hepler; Qianbin Zhang; Bo Shan; Lavanya Vishvanath; Gervaise H. Henry; Shangang Zhao; Yu A. An; Yibo Wu; Douglas W. Strand; Rana K. Gupta

doi:10.1016/j.stem.2020.12.008

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao
, Chelsea Hepler
, Qianbin Zhang
, Bo Shan
, Lavanya Vishvanath
, Gervaise H. Henry
, Shangang Zhao
, Yu A. An
, Yibo Wu
, Douglas W. Strand
, Rana K. Gupta

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

Original language	English (US)
Pages (from-to)	685-701.e7
Journal	Cell Stem Cell
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2020.12.008
State	Published - Apr 1 2021

Keywords

Adipocyte precursor cell
Adipogenesis
Fibrosis
HIF1α
Imatinib
PDGFR
PPARγ

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2020.12.008

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title = "Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity",

abstract = "How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.",

keywords = "Adipocyte precursor cell, Adipogenesis, Fibrosis, HIF1α, Imatinib, PDGFR, PPARγ",

author = "Mengle Shao and Chelsea Hepler and Qianbin Zhang and Bo Shan and Lavanya Vishvanath and Henry, \{Gervaise H.\} and Shangang Zhao and An, \{Yu A.\} and Yibo Wu and Strand, \{Douglas W.\} and Gupta, \{Rana K.\}",

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year = "2021",

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language = "English (US)",

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TY - JOUR

T1 - Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

AU - Shao, Mengle

AU - Hepler, Chelsea

AU - Zhang, Qianbin

AU - Shan, Bo

AU - Vishvanath, Lavanya

AU - Henry, Gervaise H.

AU - Zhao, Shangang

AU - An, Yu A.

AU - Wu, Yibo

AU - Strand, Douglas W.

AU - Gupta, Rana K.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

AB - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

KW - Adipocyte precursor cell

KW - Adipogenesis

KW - Fibrosis

KW - HIF1α

KW - Imatinib

KW - PDGFR

KW - PPARγ

UR - https://www.scopus.com/pages/publications/85101104487

UR - https://www.scopus.com/pages/publications/85101104487#tab=citedBy

U2 - 10.1016/j.stem.2020.12.008

DO - 10.1016/j.stem.2020.12.008

M3 - Article

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AN - SCOPUS:85101104487

SN - 1934-5909

VL - 28

SP - 685-701.e7

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Abstract

Keywords

ASJC Scopus subject areas

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