TY - JOUR
T1 - Pathogenesis of polycystic ovary syndrome
T2 - What is the role of obesity?
AU - Salehi, Marzieh
AU - Bravo-Vera, Rafael
AU - Sheikh, Arsalan
AU - Gouller, Alina
AU - Poretsky, Leonid
PY - 2004/3
Y1 - 2004/3
N2 - Both obesity and the polycystic ovary syndrome (PCOS) are commonly seen in women of reproductive age. Fifty percent of all patients with PCOS are obese, and the presence of obesity affects the clinical manifestations of PCOS. The underlying pathogenetic mechanisms appear to involve insulin resistance and hyperinsulinemia, the magnitude of which is greater in obese than in non-obese women with PCOS. Specific effects of obesity on the manifestations of PCOS, underlying mechanisms of the interactions between obesity and PCOS, and therapeutic implications of these interactions are discussed in this article.
AB - Both obesity and the polycystic ovary syndrome (PCOS) are commonly seen in women of reproductive age. Fifty percent of all patients with PCOS are obese, and the presence of obesity affects the clinical manifestations of PCOS. The underlying pathogenetic mechanisms appear to involve insulin resistance and hyperinsulinemia, the magnitude of which is greater in obese than in non-obese women with PCOS. Specific effects of obesity on the manifestations of PCOS, underlying mechanisms of the interactions between obesity and PCOS, and therapeutic implications of these interactions are discussed in this article.
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U2 - 10.1016/j.metabol.2003.10.005
DO - 10.1016/j.metabol.2003.10.005
M3 - Review article
C2 - 15015150
AN - SCOPUS:2542490223
SN - 0026-0495
VL - 53
SP - 358
EP - 376
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -