Pathogenesis of polycystic ovary syndrome: What is the role of obesity?

Marzieh Salehi, Rafael Bravo-Vera, Arsalan Sheikh, Alina Gouller, Leonid Poretsky

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


Both obesity and the polycystic ovary syndrome (PCOS) are commonly seen in women of reproductive age. Fifty percent of all patients with PCOS are obese, and the presence of obesity affects the clinical manifestations of PCOS. The underlying pathogenetic mechanisms appear to involve insulin resistance and hyperinsulinemia, the magnitude of which is greater in obese than in non-obese women with PCOS. Specific effects of obesity on the manifestations of PCOS, underlying mechanisms of the interactions between obesity and PCOS, and therapeutic implications of these interactions are discussed in this article.

Original languageEnglish (US)
Pages (from-to)358-376
Number of pages19
JournalMetabolism: Clinical and Experimental
Issue number3
StatePublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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