Pathogenesis of human immunodeficiency virus-induced neurological disease

Andrew V. Albright, Samantha S. Soldan, Francisco González-Scarano

Research output: Contribution to journalReview article

118 Scopus citations

Abstract

Infection of the central nervous system by the type 1 human immunodeficiency virus (HIV-1) commonly results in a number of neurological impairments known, in their most severe form, as HIV-associated dementia (HAD). The persistence of HIV encephalitis (HIVE), the pathological correlate of HAD, in spite of highly active antiretroviral therapy (HAART) underscores the importance of continued research focused on the neurobiology of HIV. To elucidate direct and indirect mechanisms of HIV neuropathogenesis, current investigation is focused on neuroinvasion, HIV-1-mediated mechanisms of neuronal damage and apoptosis, and compartmentalized evolution of virus in the brain. The aim of this review is to provide a selective overview of the most recent research on the neurobiology of HIV, adding only a brief introduction regarding established principles.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalJournal of NeuroVirology
Volume9
Issue number2
DOIs
StatePublished - Apr 2003

Keywords

  • Entry
  • HIV
  • Neuropathogenesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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