Pathogenesis of endometriosis - Current research

Craig A. Witz, Karen T. Allsup, Irish A. Montoya-Rodriguez, Shelby L. Vaughan, Victoria E. Centonze, Robert S Schenken

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Proliferative, secretory and menstrual endometrial cells of both the stroma and epithelium adhere to intact peritoneal mesothelium and mesothelial monolayers. Endometrial attachment to the mesothelium appears to occur rapidly (within 1 h) and transmesothelial invasion occurs between 1 and 18-24 h. These results demonstrate that the mesothelium is not a 'no-stick' surface and indicates that molecules present at the surface of the mesothelium are involved in the pathogenesis of the early endometriotic lesion. The inhibition of endometrial cell adherence to peritoneal mesothelium by hyaluronidase indicates that CD44-hyaluronan binding is at least one of the mechanisms involved in the pathogenesis of endometriosis. We believe that investigation of mesothelial cell adhesion molecules is central to understanding the pathogenesis of endometriosis.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalHuman Fertility
Volume6
Issue number1
DOIs
StatePublished - 2003

Fingerprint

Endometriosis
Epithelium
Research
Hyaluronoglucosaminidase
Cell Adhesion Molecules
Hyaluronic Acid

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Witz, C. A., Allsup, K. T., Montoya-Rodriguez, I. A., Vaughan, S. L., Centonze, V. E., & Schenken, R. S. (2003). Pathogenesis of endometriosis - Current research. Human Fertility, 6(1), 34-40. https://doi.org/10.1080/1464770312331368973

Pathogenesis of endometriosis - Current research. / Witz, Craig A.; Allsup, Karen T.; Montoya-Rodriguez, Irish A.; Vaughan, Shelby L.; Centonze, Victoria E.; Schenken, Robert S.

In: Human Fertility, Vol. 6, No. 1, 2003, p. 34-40.

Research output: Contribution to journalArticle

Witz, CA, Allsup, KT, Montoya-Rodriguez, IA, Vaughan, SL, Centonze, VE & Schenken, RS 2003, 'Pathogenesis of endometriosis - Current research', Human Fertility, vol. 6, no. 1, pp. 34-40. https://doi.org/10.1080/1464770312331368973
Witz CA, Allsup KT, Montoya-Rodriguez IA, Vaughan SL, Centonze VE, Schenken RS. Pathogenesis of endometriosis - Current research. Human Fertility. 2003;6(1):34-40. https://doi.org/10.1080/1464770312331368973
Witz, Craig A. ; Allsup, Karen T. ; Montoya-Rodriguez, Irish A. ; Vaughan, Shelby L. ; Centonze, Victoria E. ; Schenken, Robert S. / Pathogenesis of endometriosis - Current research. In: Human Fertility. 2003 ; Vol. 6, No. 1. pp. 34-40.
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