Pathogenesis of endometriosis - Current research

Craig A. Witz, Karen T. Allsup, Irish A. Montoya-Rodriguez, Shelby L. Vaughan, Victoria E. Centonze, Robert S. Schenken

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Proliferative, secretory and menstrual endometrial cells of both the stroma and epithelium adhere to intact peritoneal mesothelium and mesothelial monolayers. Endometrial attachment to the mesothelium appears to occur rapidly (within 1 h) and transmesothelial invasion occurs between 1 and 18-24 h. These results demonstrate that the mesothelium is not a 'no-stick' surface and indicates that molecules present at the surface of the mesothelium are involved in the pathogenesis of the early endometriotic lesion. The inhibition of endometrial cell adherence to peritoneal mesothelium by hyaluronidase indicates that CD44-hyaluronan binding is at least one of the mechanisms involved in the pathogenesis of endometriosis. We believe that investigation of mesothelial cell adhesion molecules is central to understanding the pathogenesis of endometriosis.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalHuman Fertility
Volume6
Issue number1
DOIs
StatePublished - May 12 2003

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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