Particulate matter (PM 10) exposure induces endothelial dysfunction and inflammation in rat brain

Lin Guo, Na Zhu, Zhen Guo, Guang ke Li, Chu Chen, Nan Sang, Qing chen Yao

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Epidemiological studies suggest that particulate matter (PM 10) inhalation was associated with adverse effects on brain-related health, however, existing experimental data lacked relevant evidences. In this study, we treated Wistar rats with PM 10 at different concentrations (0.3, 1, 3 and 10mg/kg body weight (bw)), and investigated endothelial dysfunction and inflammatory responses in the brain. The results indicate that mild pathological abnormal occurred after 15-day exposure (five times with 3 days each), followed by the changes of endothelial mediators (ET-1 and eNOS) and inflammatory markers (IL-1β, TNF-α, COX-2, iNOS and ICAM-1). Also, the sample up-regulated bax/bcl-2 ratio and p53 expression, and induced neuronal apoptosis. It implicates that PM 10 exerted injuries to mammals' brain, and the mechanisms might be involved in endothelial dysfunction and inflammatory responses.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalJournal of Hazardous Materials
Volume213-214
DOIs
StatePublished - Apr 30 2012
Externally publishedYes

Keywords

  • Apoptosis
  • Brain
  • Endothelial dysfunction
  • Inflammatory response
  • PM

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

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