Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Shangang Zhao; Yi Zhu; Robbie D. Schultz; Na Li; Zhenyan He; Zhuzhen Zhang; Alexandre Caron; Qingzhang Zhu; Kai Sun; Wei Xiong; Hui Deng; Jia Sun; Yingfeng Deng; Min Kim; Charlotte E. Lee; Ruth Gordillo; Tiemin Liu; Angela K. Odle; Gwen V. Childs; Ningyan Zhang; Christine M. Kusminski; Joel K. Elmquist; Kevin W. Williams; Zhiqiang An; Philipp E. Scherer

doi:10.1016/j.cmet.2019.08.005

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Shangang Zhao
, Yi Zhu
, Robbie D. Schultz
, Na Li
, Zhenyan He
, Zhuzhen Zhang
, Alexandre Caron
, Qingzhang Zhu
, Kai Sun
, Wei Xiong
, Hui Deng
, Jia Sun
, Yingfeng Deng
, Min Kim
, Charlotte E. Lee
, Ruth Gordillo
, Tiemin Liu
, Angela K. Odle
, Gwen V. Childs
, Ningyan Zhang

Christine M. Kusminski, Joel K. Elmquist, Kevin W. Williams, Zhiqiang An, Philipp E. Scherer

Research output: Contribution to journal › Article › peer-review

249 Scopus citations

Abstract

Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic leptin sensitivity and leads to reduced food intake, increased energy expenditure, and improved insulin sensitivity. Thus, strategies aimed at partially reducing circulating leptin may represent a promising approach for the treatment of obesity and diabetes.

Original language	English (US)
Pages (from-to)	706-719.e6
Journal	Cell Metabolism
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2019.08.005
State	Published - Oct 1 2019

Keywords

diabetes
hypothalamus
leptin
leptin resistance
obesity

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.08.005

Cite this

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., ... Scherer, P. E. (2019). Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metabolism, 30(4), 706-719.e6. https://doi.org/10.1016/j.cmet.2019.08.005

Zhao, S, Zhu, Y, Schultz, RD, Li, N, He, Z, Zhang, Z, Caron, A, Zhu, Q, Sun, K, Xiong, W, Deng, H, Sun, J, Deng, Y, Kim, M, Lee, CE, Gordillo, R, Liu, T, Odle, AK, Childs, GV, Zhang, N, Kusminski, CM, Elmquist, JK, Williams, KW, An, Z & Scherer, PE 2019, 'Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy', Cell Metabolism, vol. 30, no. 4, pp. 706-719.e6. https://doi.org/10.1016/j.cmet.2019.08.005

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title = "Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy",

abstract = "Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic leptin sensitivity and leads to reduced food intake, increased energy expenditure, and improved insulin sensitivity. Thus, strategies aimed at partially reducing circulating leptin may represent a promising approach for the treatment of obesity and diabetes.",

keywords = "diabetes, hypothalamus, leptin, leptin resistance, obesity",

author = "Shangang Zhao and Yi Zhu and Schultz, \{Robbie D.\} and Na Li and Zhenyan He and Zhuzhen Zhang and Alexandre Caron and Qingzhang Zhu and Kai Sun and Wei Xiong and Hui Deng and Jia Sun and Yingfeng Deng and Min Kim and Lee, \{Charlotte E.\} and Ruth Gordillo and Tiemin Liu and Odle, \{Angela K.\} and Childs, \{Gwen V.\} and Ningyan Zhang and Kusminski, \{Christine M.\} and Elmquist, \{Joel K.\} and Williams, \{Kevin W.\} and Zhiqiang An and Scherer, \{Philipp E.\}",

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doi = "10.1016/j.cmet.2019.08.005",

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AU - Caron, Alexandre

AU - Zhu, Qingzhang

AU - Sun, Kai

AU - Xiong, Wei

AU - Deng, Hui

AU - Sun, Jia

AU - Deng, Yingfeng

AU - Kim, Min

AU - Lee, Charlotte E.

AU - Gordillo, Ruth

AU - Liu, Tiemin

AU - Odle, Angela K.

AU - Childs, Gwen V.

AU - Zhang, Ningyan

AU - Kusminski, Christine M.

AU - Elmquist, Joel K.

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AU - An, Zhiqiang

AU - Scherer, Philipp E.

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KW - hypothalamus

KW - leptin

KW - leptin resistance

KW - obesity

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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Abstract

Keywords

ASJC Scopus subject areas

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