Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Shangang Zhao, Yi Zhu, Robbie D. Schultz, Na Li, Zhenyan He, Zhuzhen Zhang, Alexandre Caron, Qingzhang Zhu, Kai Sun, Wei Xiong, Hui Deng, Jia Sun, Yingfeng Deng, Min Kim, Charlotte E. Lee, Ruth Gordillo, Tiemin Liu, Angela K. Odle, Gwen V. Childs, Ningyan ZhangChristine M. Kusminski, Joel K. Elmquist, Kevin W. Williams, Zhiqiang An, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic leptin sensitivity and leads to reduced food intake, increased energy expenditure, and improved insulin sensitivity. Thus, strategies aimed at partially reducing circulating leptin may represent a promising approach for the treatment of obesity and diabetes.

Original languageEnglish (US)
Pages (from-to)706-719.e6
JournalCell Metabolism
Issue number4
StatePublished - Oct 1 2019


  • diabetes
  • hypothalamus
  • leptin
  • leptin resistance
  • obesity

ASJC Scopus subject areas

  • Molecular Biology
  • Physiology
  • Cell Biology


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