Pars intermedia electrical potentials: Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (msh) secretion

M. D. Davis; M. E. Hadley

doi:10.1159/000122783

Pars intermedia electrical potentials: Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (msh) secretion

M. D. Davis, M. E. Hadley

Pharmacology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Spontaneous action potentials recorded from pars intermedia (PI) cells of frog pituitaries are correlated with spontaneous melanophore stimulating hormone (MSH) secretion from that gland. Those agents known to induce hormone release (e.g., serotonin, isoproterenol) increase the rate of electrical activity, whereas those which inhibit secretion (e.g., norepinephrine, dopamine, GABA) reduce the frequency of spikes. MSH secretion appears to involve cellular depolarization while inhibition of release is associated with cell membrane polarization.

Original language	English (US)
Pages (from-to)	277-282
Number of pages	6
Journal	Neuroendocrinology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1159/000122783
State	Published - 1978

Keywords

Electrical potentials
MSH
Pars intermedia
Regulatory factors

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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AB - Spontaneous action potentials recorded from pars intermedia (PI) cells of frog pituitaries are correlated with spontaneous melanophore stimulating hormone (MSH) secretion from that gland. Those agents known to induce hormone release (e.g., serotonin, isoproterenol) increase the rate of electrical activity, whereas those which inhibit secretion (e.g., norepinephrine, dopamine, GABA) reduce the frequency of spikes. MSH secretion appears to involve cellular depolarization while inhibition of release is associated with cell membrane polarization.

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Pars intermedia electrical potentials: Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (msh) secretion

Abstract

Keywords

ASJC Scopus subject areas

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