Pars intermedia electrical potentials: Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (MSH) secretion

M. D. Davis, M. E. Hadley

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Spontaneous action potentials recorded from pars intermedia (PI) cells of frog pituitaries are correlated with spontaneous melanophore stimulating hormone (MSH) secretion from that gland. Those agents known to induce hormone release (e.g., serotonin, isoproterenol) increase the rate of electrical activity, whereas those which inhibit secretion (e.g., norepinephrine, dopamine, GABA) reduce the frequency of spikes. MSH secretion appears to involve cellular depolarization while inhibition of release is associated with cell membrane polarization.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalNeuroendocrinology
Volume26
Issue number5
StatePublished - 1978
Externally publishedYes

Fingerprint

Melanocyte-Stimulating Hormones
Isoproterenol
Anura
gamma-Aminobutyric Acid
Action Potentials
Dopamine
Serotonin
Norepinephrine
Cell Membrane
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Pars intermedia electrical potentials : Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (MSH) secretion. / Davis, M. D.; Hadley, M. E.

In: Neuroendocrinology, Vol. 26, No. 5, 1978, p. 277-282.

Research output: Contribution to journalArticle

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