Pars intermedia electrical potentials: Changes in spike frequency induced by regulatory factors of melanocyte stimulating hormone (msh) secretion

M. D. Davis, M. E. Hadley

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Spontaneous action potentials recorded from pars intermedia (PI) cells of frog pituitaries are correlated with spontaneous melanophore stimulating hormone (MSH) secretion from that gland. Those agents known to induce hormone release (e.g., serotonin, isoproterenol) increase the rate of electrical activity, whereas those which inhibit secretion (e.g., norepinephrine, dopamine, GABA) reduce the frequency of spikes. MSH secretion appears to involve cellular depolarization while inhibition of release is associated with cell membrane polarization.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalNeuroendocrinology
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1978

Keywords

  • Electrical potentials
  • MSH
  • Pars intermedia
  • Regulatory factors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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