PARATHYROID HORMONE AND EXPERIMENTAL OSTEOSCLEROSIS

D. N. Kalu; Jacqueline Pennock; F. H. Doyle; G. V. Foster

doi:10.1016/S0140-6736(70)91271-7

PARATHYROID HORMONE AND EXPERIMENTAL OSTEOSCLEROSIS

D. N. Kalu, Jacqueline Pennock, F. H. Doyle, G. V. Foster

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Tests were done in growing rats to see whether the osteosclerotic changes provoked by parathyroid extract could be due to a compensatory secretion of calcitonin. Parathyroid extract increased metaphyseal bone in both intact and thyroparathyroidectomised animals. Likewise, peptide-pure parathyroid hormone induced similar changes in thyroparathyroidectomised rats. Incorporation of ³H-proline into bone hydroxyproline in these animals was strikingly augmented. It is concluded that (1) parathyroid-extract-induced osteosclerosis is not due to compensatory changes in calcitonin secretion; (2) parathyroid hormone itself, and not a contaminating peptide, is the cause; and (3) parathyroid hormone induces osteosclerosis by increasing bone formation, unlike calcitonin which does so by inhibiting bone resorption.

Original language	English (US)
Pages (from-to)	1363-1366
Number of pages	4
Journal	The Lancet
Volume	295
Issue number	7661
DOIs	https://doi.org/10.1016/S0140-6736(70)91271-7
State	Published - Jun 27 1970
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(70)91271-7

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abstract = "Tests were done in growing rats to see whether the osteosclerotic changes provoked by parathyroid extract could be due to a compensatory secretion of calcitonin. Parathyroid extract increased metaphyseal bone in both intact and thyroparathyroidectomised animals. Likewise, peptide-pure parathyroid hormone induced similar changes in thyroparathyroidectomised rats. Incorporation of 3H-proline into bone hydroxyproline in these animals was strikingly augmented. It is concluded that (1) parathyroid-extract-induced osteosclerosis is not due to compensatory changes in calcitonin secretion; (2) parathyroid hormone itself, and not a contaminating peptide, is the cause; and (3) parathyroid hormone induces osteosclerosis by increasing bone formation, unlike calcitonin which does so by inhibiting bone resorption.",

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AU - Pennock, Jacqueline

AU - Doyle, F. H.

AU - Foster, G. V.

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PARATHYROID HORMONE AND EXPERIMENTAL OSTEOSCLEROSIS

Abstract

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