Parasite-parasite interaction of Salmonella typhimurium and Schistosoma

P. T. LoVerde, C. Amento, G. I. Higashi

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Abstract

The parasite-parasite interaction of Salmonella and Schistosoma was studied. Salmonella typhimurium LT2 was found to associate in vitro with three human species of Schistosoma: Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Genetic mutants of S. typhimurium were allowed to interact with ligatured and unligatured worms of S. mansoni in vitro. These studies were undertaken to elucide the mechanism(s) of the parasite-parasite interaction of Salmonella on the surface of Schistosoma. The galE and fla mutants showed 100% association with male schistosomes, but a reduced interaction with female worms. The rough A and pili mutants showed a significant reduction in the ability to associate with both male and female S. mansoni. Observations with the scanning electron microscope revealed that pili function in adhesion of Salmonella to the surface tegument of S. mansoni haematobium. The association of Salmonella and Schistosoma may contribute to persistence of salmonella infection.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalJournal of Infectious Diseases
Volume141
Issue number2
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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