Paraoxonase (PON)-1: A brief overview on genetics, structure, polymorphisms and clinical relevance

Nelusha Shunmoogam, Poobalan Naidoo, Robert Chilton

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated to play a role in several human diseases including diabetes mellitus and atherosclerosis. Low PON1 activity has been associated with increased risk of major cardiovascular events, therefore a variety of studies have been conducted to establish the cardioprotective properties and clinical relevance of PON1. The major aim of this review was to highlight the important studies and to subsequently assess if PON1 has clinical relevance. A review of the literature showed that there is currently insufficient data to suggest that PON1 has clinical relevance. It is our opinion that robust studies are required to clarify the clinical relevance of PON1.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalVascular Health and Risk Management
StatePublished - Jun 18 2018


  • Antioxidant
  • Atherosclerosis
  • Cardiovascular disease
  • Inflammation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Hematology
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Paraoxonase (PON)-1: A brief overview on genetics, structure, polymorphisms and clinical relevance'. Together they form a unique fingerprint.

Cite this