Paraoxonase (PON)-1: A brief overview on genetics, structure, polymorphisms and clinical relevance

Nelusha Shunmoogam, Poobalan Naidoo, Robert J Chilton

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated to play a role in several human diseases including diabetes mellitus and atherosclerosis. Low PON1 activity has been associated with increased risk of major cardiovascular events, therefore a variety of studies have been conducted to establish the cardioprotective properties and clinical relevance of PON1. The major aim of this review was to highlight the important studies and to subsequently assess if PON1 has clinical relevance. A review of the literature showed that there is currently insufficient data to suggest that PON1 has clinical relevance. It is our opinion that robust studies are required to clarify the clinical relevance of PON1.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalVascular Health and Risk Management
Volume14
DOIs
StatePublished - Jun 18 2018

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Keywords

  • Antioxidant
  • Atherosclerosis
  • Cardiovascular disease
  • Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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