Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin

Allison Grimes, Nooshin Mirkheshti, Bandana Chatterjee, Gail Tomlinson, Chatchawin Assanasen

Research output: Contribution to journalArticle

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free survival in recent decades, the lack of reliable prognosticators and high rate of relapse remain a challenge. Described is a novel discovery of tumor-derived hyperprolactinemia in childhood T-ALL through a case associated with paraneoplastic galactorrhea. Prolactin production by tumor cells, although a rare phenomenon, is previously demonstrated in several adult cancers and 2 pediatric malignancies with unknown implications. This is the first report demonstrating tumor-derived prolactin in pediatric T-ALL and offers potential as a disease marker and therapeutic drug target.

Original languageEnglish (US)
JournalJournal of Pediatric Hematology/Oncology
DOIs
StateAccepted/In press - Nov 4 2016

Fingerprint

Galactorrhea
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Prolactin
Neoplasms
Pediatrics
Hyperprolactinemia
Disease-Free Survival
Leukemia
Recurrence
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Paraneoplastic Galactorrhea in Childhood T-ALL : An Evaluation of Tumor-derived Prolactin. / Grimes, Allison; Mirkheshti, Nooshin; Chatterjee, Bandana; Tomlinson, Gail; Assanasen, Chatchawin.

In: Journal of Pediatric Hematology/Oncology, 04.11.2016.

Research output: Contribution to journalArticle

@article{88373c4071fa43819f71421d5370fc04,
title = "Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin",
abstract = "T-cell acute lymphoblastic leukemia (T-ALL) comprises 15{\%} of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free survival in recent decades, the lack of reliable prognosticators and high rate of relapse remain a challenge. Described is a novel discovery of tumor-derived hyperprolactinemia in childhood T-ALL through a case associated with paraneoplastic galactorrhea. Prolactin production by tumor cells, although a rare phenomenon, is previously demonstrated in several adult cancers and 2 pediatric malignancies with unknown implications. This is the first report demonstrating tumor-derived prolactin in pediatric T-ALL and offers potential as a disease marker and therapeutic drug target.",
author = "Allison Grimes and Nooshin Mirkheshti and Bandana Chatterjee and Gail Tomlinson and Chatchawin Assanasen",
year = "2016",
month = "11",
day = "4",
doi = "10.1097/MPH.0000000000000677",
language = "English (US)",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Paraneoplastic Galactorrhea in Childhood T-ALL

T2 - An Evaluation of Tumor-derived Prolactin

AU - Grimes, Allison

AU - Mirkheshti, Nooshin

AU - Chatterjee, Bandana

AU - Tomlinson, Gail

AU - Assanasen, Chatchawin

PY - 2016/11/4

Y1 - 2016/11/4

N2 - T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free survival in recent decades, the lack of reliable prognosticators and high rate of relapse remain a challenge. Described is a novel discovery of tumor-derived hyperprolactinemia in childhood T-ALL through a case associated with paraneoplastic galactorrhea. Prolactin production by tumor cells, although a rare phenomenon, is previously demonstrated in several adult cancers and 2 pediatric malignancies with unknown implications. This is the first report demonstrating tumor-derived prolactin in pediatric T-ALL and offers potential as a disease marker and therapeutic drug target.

AB - T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free survival in recent decades, the lack of reliable prognosticators and high rate of relapse remain a challenge. Described is a novel discovery of tumor-derived hyperprolactinemia in childhood T-ALL through a case associated with paraneoplastic galactorrhea. Prolactin production by tumor cells, although a rare phenomenon, is previously demonstrated in several adult cancers and 2 pediatric malignancies with unknown implications. This is the first report demonstrating tumor-derived prolactin in pediatric T-ALL and offers potential as a disease marker and therapeutic drug target.

UR - http://www.scopus.com/inward/record.url?scp=84994551688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994551688&partnerID=8YFLogxK

U2 - 10.1097/MPH.0000000000000677

DO - 10.1097/MPH.0000000000000677

M3 - Article

C2 - 27820136

AN - SCOPUS:84994551688

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

ER -