Parabrachial nucleus modulation of vasopressin release

L. E. Ohman, R. E. Shade, J. R. Haywood

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations

    Abstract

    The present studies examine the contribution of the ventrolateral lateral parabrachial nucleus (VLLPBN) to the regulation of plasma arginine vasopressin (P(AVP)) release in response to either a baroreceptor or osmotic stimulus. These studies were carried out in rats with bilateral electrolytic lesions of the VLLPBN. Baroreceptor-induced stimulation of P(AVP) was achieved by decreasing blood pressure with combined blockade of the renin-angiotensin system with captopril (3 mg/kg iv) and the sympathetic nervous system with chlorisondamine, (11 mg/kg sc). Osmotic release of vasopressin was elicited by a 2-h intravenous infusion of hypertonic saline, (3.0 meq/ml, 0.01 ml/min). Blood pressure and heart rate were monitored throughout the experiments. Blood samples for determination of P(AVP), plasma osmolality P(osm), plasma sodium (P(Na)), and plasma potassium (P(K)) were taken before (base line) and after treatment in each study. The VLLPBN-lesioned rats secreted significantly more vasopressin in response to hypotension produced by combined renin-angiotensin and sympathetic nervous system blockade than did control rats. There was no significant difference between groups in P(osm), P(Na), or P(K), or cardiovascular changes. In contrast, hypertonic saline infusion did not produce any differential changes between groups.

    Original languageEnglish (US)
    Pages (from-to)R358-R364
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume258
    Issue number2 27-2
    DOIs
    StatePublished - 1990

    Keywords

    • baroreceptor
    • blood pressure
    • hyperosmolality
    • pons

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Fingerprint Dive into the research topics of 'Parabrachial nucleus modulation of vasopressin release'. Together they form a unique fingerprint.

    Cite this