Parabrachial lesions increase plasma norepinephrine concentration, plasma renin activity and enhance baroreflex sensitivity in the conscious rat

J. W. Hubbard, R. A. Buchholz, T. K. Keeton, M. A. Nathan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Electrolytic lesions of the parabrachial nucleus (PBN) caused significant increases in basal plasma renin activity (+433%) and basal plasma norepinephrine concentration (+98%) in conscious rats. Plasma epinephrine concentration, mean arterial pressure, heart rate, hematocrit, plasma osmolality and plasma sodium and potassium concentrations were not significantly affected by the lesions. Atenolol reduced the elevated plasma renin activity in the lesion group to a value similar to that of a control group (sham lesions or lesions in areas adjacent to the PBN). Captopril significantly lowered mean arterial pressure in the lesion group, but it had no effect on arterial pressure in the control group. Lesions of the PBN also increased the baroreflex-mediated bradycardia evoked by an abrupt elevation of arterial pressure. We propose that the PBN tonically inhibits sympathetic activity, sympathetically mediated renin release and baroreflex sensitivity.

Original languageEnglish (US)
Pages (from-to)226-234
Number of pages9
JournalBrain Research
Volume421
Issue number1-2
DOIs
StatePublished - Sep 22 1987

Keywords

  • Baroreflex
  • Parabrachial nucleus (PBN)
  • Plasma norepinephrine
  • Plasma renin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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