Papio spp. Colon microbiome and its link to obesity in pregnancy

Xuan Ji Li; Christopher Rensing; William L. Taylor; Caitlin Costelle; Asker Daniel Brejnrod; Robert J. Ferry; Paul B. Higgins; Franco Folli; Kameswara Rao Kottapalli; Gene B. Hubbard; Edward J. Dick; Shibu Yooseph; Karen E. Nelson; Natalia Schlabritz-Loutsevitch

doi:10.1111/jmp.12366

Papio spp. Colon microbiome and its link to obesity in pregnancy

Xuan Ji Li, Christopher Rensing, William L. Taylor, Caitlin Costelle, Asker Daniel Brejnrod, Robert J. Ferry, Paul B. Higgins, Franco Folli, Kameswara Rao Kottapalli, Gene B. Hubbard, Edward J. Dick, Shibu Yooseph, Karen E. Nelson, Natalia Schlabritz-Loutsevitch

Research output: Contribution to journal › Article

Abstract

Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Material and methods: Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test. Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups. Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.

Original language	English (US)
Pages (from-to)	393-401
Number of pages	9
Journal	Journal of medical primatology
Volume	47
Issue number	6
DOIs	https://doi.org/10.1111/jmp.12366
State	Published - Dec 2018

Keywords

baboon
microbiome
obesity
pregnancy

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/jmp.12366

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Li, X. J., Rensing, C., Taylor, W. L., Costelle, C., Brejnrod, A. D., Ferry, R. J., Higgins, P. B., Folli, F., Kottapalli, K. R., Hubbard, G. B., Dick, E. J., Yooseph, S., Nelson, K. E., & Schlabritz-Loutsevitch, N. (2018). Papio spp. Colon microbiome and its link to obesity in pregnancy. Journal of medical primatology, 47(6), 393-401. https://doi.org/10.1111/jmp.12366

Papio spp. Colon microbiome and its link to obesity in pregnancy. / Li, Xuan Ji; Rensing, Christopher; Taylor, William L.; Costelle, Caitlin; Brejnrod, Asker Daniel; Ferry, Robert J.; Higgins, Paul B.; Folli, Franco; Kottapalli, Kameswara Rao; Hubbard, Gene B.; Dick, Edward J.; Yooseph, Shibu; Nelson, Karen E.; Schlabritz-Loutsevitch, Natalia.

In: Journal of medical primatology, Vol. 47, No. 6, 12.2018, p. 393-401.

Research output: Contribution to journal › Article

Li, Xuan Ji ; Rensing, Christopher ; Taylor, William L. ; Costelle, Caitlin ; Brejnrod, Asker Daniel ; Ferry, Robert J. ; Higgins, Paul B. ; Folli, Franco ; Kottapalli, Kameswara Rao ; Hubbard, Gene B. ; Dick, Edward J. ; Yooseph, Shibu ; Nelson, Karen E. ; Schlabritz-Loutsevitch, Natalia. / Papio spp. Colon microbiome and its link to obesity in pregnancy. In: Journal of medical primatology. 2018 ; Vol. 47, No. 6. pp. 393-401.

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abstract = "Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Material and methods: Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test. Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups. Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.",

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