@article{44430763468e4a6aafe37e5039e91f3e,
title = "Papio spp. Colon microbiome and its link to obesity in pregnancy",
abstract = "Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Material and methods: Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test. Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups. Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.",
keywords = "baboon, microbiome, obesity, pregnancy",
author = "Li, {Xuan Ji} and Christopher Rensing and Taylor, {William L.} and Caitlin Costelle and Brejnrod, {Asker Daniel} and Ferry, {Robert J.} and Higgins, {Paul B.} and Franco Folli and Kottapalli, {Kameswara Rao} and Hubbard, {Gene B.} and Dick, {Edward J.} and Shibu Yooseph and Nelson, {Karen E.} and Natalia Schlabritz-Loutsevitch",
note = "Funding Information: We acknowledge the help and dedication of the many excellent animal caretakers, technicians, and veterinarians of the Southwest National Primate Center. Fantastic help of Mrs. Felicia Waller in molecular biology experiments is greatly appreciated. We would like to acknowledge the contribution of Ms. Melissa Waggoner in manuscript editing. This investigation was supported by Southwest National Primate Research Center grant P51 RR013986 from the National Center for Research Resources and the National Institutes of Health, which are currently supported by the Office of Research Infrastructure Programs through P51 OD011133. This investigation was conducted in facilities constructed with support from the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health through grant numbers C06 RR015456 and C06 RR014578. Funding (to N.S-L) for sequencing was provided by the Center for Integrative and Translational Genomics at the University of Tennessee Health Science Center. The research was also supported by a New Investigator (UTHSCSA) grant, Southwest National Primate Center Pilot, UTHSC Center for Integrated and Translational Genomics, and TTUHSC start-up grants to N.S-L., as well as NIH grant HD21350 to Dr. Peter Nathanielsz (UTHSCSA). Authors are thankful to Ms. Stacy Martinez (TTUHSC) for performance of DNA extraction and PCR and Dr. Y. Kobozev (TTU) for his help in data analyses. Research in the laboratory of C.R was funded by the 100 talents plan of Fujian province. Authors acknowledge continuous support of Dr. Gary Ventolini (Regional Dean of TTUHSC SOM at the PB campus). Funding Information: National Institutes of Health, Grant/Award Number: C06 RR014578, C06 RR015456, HD21350, P51 OD011133 and P51 RR013986; Texas Tech University Health Sciences Center start-up grants; Center for Integrative and Translational Genomics at the University of Tennessee Health Science Center; New Investigator Grant (UTHSCSA); Southwest National Primate Cetner Pilot; National Center for Research Resources; UTHSC Center for Integrated and Translational Genomics; TTUHSC Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = dec,
doi = "10.1111/jmp.12366",
language = "English (US)",
volume = "47",
pages = "393--401",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "6",
}