PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Li Ling Lin; Edward R. Kost; Chun Lin Lin; Philip Valente; Chiou Miin Wang; Mikhail G. Kolonin; Alexes C. Daquinag; Xi Tan; Nicholas Lucio; Chia Nung Hung; Chen Pin Wang; Nameer B. Kirma; Tim H.M. Huang

doi:10.1016/j.celrep.2020.108253

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Li Ling Lin
, Edward R. Kost
, Chun Lin Lin
, Philip Valente
, Chiou Miin Wang
, Mikhail G. Kolonin
, Alexes C. Daquinag
, Xi Tan
, Nicholas Lucio
, Chia Nung Hung
, Chen Pin Wang
, Nameer B. Kirma
, Tim H.M. Huang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

Original language	English (US)
Article number	108253
Journal	Cell Reports
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.108253
State	Published - Oct 13 2020

Keywords

LRP1
PAI-1
SMAD4
adipose stromal cells
cell-cell communication
cytometry by time-of-flight
endometrial cancer
obesity
single-cell analysis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108253

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Lin, L. L., Kost, E. R., Lin, C. L., Valente, P., Wang, C. M., Kolonin, M. G., Daquinag, A. C., Tan, X., Lucio, N., Hung, C. N., Wang, C. P., Kirma, N. B., & Huang, T. H. M. (2020). PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. Cell Reports, 33(2), Article 108253. https://doi.org/10.1016/j.celrep.2020.108253

@article{1c5be0372fa74b2bb9de151a7305543f,

title = "PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer",

abstract = "Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.",

keywords = "LRP1, PAI-1, SMAD4, adipose stromal cells, cell-cell communication, cytometry by time-of-flight, endometrial cancer, obesity, single-cell analysis",

author = "Lin, \{Li Ling\} and Kost, \{Edward R.\} and Lin, \{Chun Lin\} and Philip Valente and Wang, \{Chiou Miin\} and Kolonin, \{Mikhail G.\} and Daquinag, \{Alexes C.\} and Xi Tan and Nicholas Lucio and Hung, \{Chia Nung\} and Wang, \{Chen Pin\} and Kirma, \{Nameer B.\} and Huang, \{Tim H.M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = oct,

day = "13",

doi = "10.1016/j.celrep.2020.108253",

language = "English (US)",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

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TY - JOUR

T1 - PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

AU - Lin, Li Ling

AU - Kost, Edward R.

AU - Lin, Chun Lin

AU - Valente, Philip

AU - Wang, Chiou Miin

AU - Kolonin, Mikhail G.

AU - Daquinag, Alexes C.

AU - Tan, Xi

AU - Lucio, Nicholas

AU - Hung, Chia Nung

AU - Wang, Chen Pin

AU - Kirma, Nameer B.

AU - Huang, Tim H.M.

PY - 2020/10/13

Y1 - 2020/10/13

N2 - Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

AB - Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

KW - LRP1

KW - PAI-1

KW - SMAD4

KW - adipose stromal cells

KW - cell-cell communication

KW - cytometry by time-of-flight

KW - endometrial cancer

KW - obesity

KW - single-cell analysis

UR - https://www.scopus.com/pages/publications/85092483380

UR - https://www.scopus.com/pages/publications/85092483380#tab=citedBy

U2 - 10.1016/j.celrep.2020.108253

DO - 10.1016/j.celrep.2020.108253

M3 - Article

C2 - 33053339

AN - SCOPUS:85092483380

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 2

M1 - 108253

ER -

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Abstract

Keywords

ASJC Scopus subject areas

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