PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Li Ling Lin; Edward R. Kost; Chun Lin Lin; Philip Valente; Chiou Miin Wang; Mikhail G. Kolonin; Alexes C. Daquinag; Xi Tan; Nicholas Lucio; Chia Nung Hung; Chen Pin Wang; Nameer B. Kirma; Tim H.M. Huang

doi:10.1016/j.celrep.2020.108253

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Li Ling Lin, Edward R. Kost, Chun Lin Lin, Philip Valente, Chiou Miin Wang, Mikhail G. Kolonin, Alexes C. Daquinag, Xi Tan, Nicholas Lucio, Chia Nung Hung, Chen Pin Wang, Nameer B. Kirma, Tim H.M. Huang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

Original language	English (US)
Article number	108253
Journal	Cell Reports
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.108253
State	Published - Oct 13 2020

Keywords

LRP1
PAI-1
SMAD4
adipose stromal cells
cell-cell communication
cytometry by time-of-flight
endometrial cancer
obesity
single-cell analysis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108253

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Lin, L. L., Kost, E. R., Lin, C. L., Valente, P., Wang, C. M., Kolonin, M. G., Daquinag, A. C., Tan, X., Lucio, N., Hung, C. N., Wang, C. P., Kirma, N. B., & Huang, T. H. M. (2020). PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. Cell Reports, 33(2), Article 108253. https://doi.org/10.1016/j.celrep.2020.108253

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title = "PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer",

abstract = "Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.",

keywords = "LRP1, PAI-1, SMAD4, adipose stromal cells, cell-cell communication, cytometry by time-of-flight, endometrial cancer, obesity, single-cell analysis",

author = "Lin, {Li Ling} and Kost, {Edward R.} and Lin, {Chun Lin} and Philip Valente and Wang, {Chiou Miin} and Kolonin, {Mikhail G.} and Daquinag, {Alexes C.} and Xi Tan and Nicholas Lucio and Hung, {Chia Nung} and Wang, {Chen Pin} and Kirma, {Nameer B.} and Huang, {Tim H.M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = oct,

day = "13",

doi = "10.1016/j.celrep.2020.108253",

language = "English (US)",

volume = "33",

journal = "Cell Reports",

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TY - JOUR

T1 - PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

AU - Lin, Li Ling

AU - Kost, Edward R.

AU - Lin, Chun Lin

AU - Valente, Philip

AU - Wang, Chiou Miin

AU - Kolonin, Mikhail G.

AU - Daquinag, Alexes C.

AU - Tan, Xi

AU - Lucio, Nicholas

AU - Hung, Chia Nung

AU - Wang, Chen Pin

AU - Kirma, Nameer B.

AU - Huang, Tim H.M.

PY - 2020/10/13

Y1 - 2020/10/13

N2 - Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

AB - Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

KW - LRP1

KW - PAI-1

KW - SMAD4

KW - adipose stromal cells

KW - cell-cell communication

KW - cytometry by time-of-flight

KW - endometrial cancer

KW - obesity

KW - single-cell analysis

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U2 - 10.1016/j.celrep.2020.108253

DO - 10.1016/j.celrep.2020.108253

M3 - Article

C2 - 33053339

AN - SCOPUS:85092483380

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 2

M1 - 108253

ER -

PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Abstract

Keywords

ASJC Scopus subject areas

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