PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

Li Ling Lin, Edward R. Kost, Chun Lin Lin, Philip Valente, Chiou Miin Wang, Mikhail G. Kolonin, Alexes C. Daquinag, Xi Tan, Nicholas Lucio, Chia Nung Hung, Chen Pin Wang, Nameer B. Kirma, Tim H.M. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.

Original languageEnglish (US)
Article number108253
JournalCell Reports
Volume33
Issue number2
DOIs
StatePublished - Oct 13 2020

Keywords

  • LRP1
  • PAI-1
  • SMAD4
  • adipose stromal cells
  • cell-cell communication
  • cytometry by time-of-flight
  • endometrial cancer
  • obesity
  • single-cell analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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