@article{1c5be0372fa74b2bb9de151a7305543f,
title = "PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer",
abstract = "Lin et al. demonstrate that PAI-1 secreted by adipose stromal cells interacts with LRP1 to repress TGF-β/SMAD4-regulated genes linked to cellular junction and adhesion complexes. This action disrupts cell-cell communication and facilitates the development of obesity-driven endometrial cancer.",
keywords = "LRP1, PAI-1, SMAD4, adipose stromal cells, cell-cell communication, cytometry by time-of-flight, endometrial cancer, obesity, single-cell analysis",
author = "Lin, {Li Ling} and Kost, {Edward R.} and Lin, {Chun Lin} and Philip Valente and Wang, {Chiou Miin} and Kolonin, {Mikhail G.} and Daquinag, {Alexes C.} and Xi Tan and Nicholas Lucio and Hung, {Chia Nung} and Wang, {Chen Pin} and Kirma, {Nameer B.} and Huang, {Tim H.M.}",
note = "Funding Information: The authors acknowledge the assistance of the University of Texas Health San Antonio Next-Generation Sequencing Core for RNA-seq; the Bioanalytics and Single-Cell Core for single-cell capture and sequencing library generation as well as CyTOF Mass Cytometry studies; and the Optical Imaging Core Facility for confocal microscopy. This work was supported by NIH grants R01 CA172279 and P30 CA054174 , the Cancer Prevention and Research Institute of Texas (CPRIT) grant RP150600 , the San Antonio Cancer Council , and the Max and Minnie Tomerlin Voelcker Fund . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = oct,
day = "13",
doi = "10.1016/j.celrep.2020.108253",
language = "English (US)",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}