PAF molecular heterogeneity: Pathobiological implications

Linda M Mcmanus, D. S. Woodard, S. I. Deavers, R. N Pinckard

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)639-650
Number of pages12
JournalLaboratory Investigation
Volume69
Issue number6
StatePublished - 1993

Fingerprint

Autacoids
Platelet Activating Factor
Phospholipids
Research Personnel
In Vitro Techniques

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

PAF molecular heterogeneity : Pathobiological implications. / Mcmanus, Linda M; Woodard, D. S.; Deavers, S. I.; Pinckard, R. N.

In: Laboratory Investigation, Vol. 69, No. 6, 1993, p. 639-650.

Research output: Contribution to journalArticle

Mcmanus, Linda M ; Woodard, D. S. ; Deavers, S. I. ; Pinckard, R. N. / PAF molecular heterogeneity : Pathobiological implications. In: Laboratory Investigation. 1993 ; Vol. 69, No. 6. pp. 639-650.
@article{ec8bda2c5a85461a9bfaf3a0a441996d,
title = "PAF molecular heterogeneity: Pathobiological implications",
abstract = "The existence and potential (patho)physiologic significance of PAF molecular heterogeneity can no longer be summarily dismissed or ignored. While significant advances in the chemistry of PAF have been made, the (patho)physiologic behaviors of most of the PAF molecular species of biologic origin await further study. This is because to date, investigators have studied the biologic activities of what was previously thought to be PAF, i.e., only 16:0- and 18:0-AGEPC. In view of the evidence presented in this review, a comprehensive investigation of the possible biologic relevance and significance of PAF molecular heterogeneity is warranted. Hopefully, such studies will be designed to elucidate the extent to which the various molecular species of PAF differ in their intrinsic in vitro and in vivo (patho)physiologic behaviors (agonistic, synergistic, and possibly antagonistic) and modes of action. Once this additional information has been derived, the pathobiologic relevance of this class of phospholipid autacoid may be better understood.",
author = "Mcmanus, {Linda M} and Woodard, {D. S.} and Deavers, {S. I.} and Pinckard, {R. N}",
year = "1993",
language = "English",
volume = "69",
pages = "639--650",
journal = "Laboratory Investigation",
issn = "0023-6837",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - PAF molecular heterogeneity

T2 - Pathobiological implications

AU - Mcmanus, Linda M

AU - Woodard, D. S.

AU - Deavers, S. I.

AU - Pinckard, R. N

PY - 1993

Y1 - 1993

N2 - The existence and potential (patho)physiologic significance of PAF molecular heterogeneity can no longer be summarily dismissed or ignored. While significant advances in the chemistry of PAF have been made, the (patho)physiologic behaviors of most of the PAF molecular species of biologic origin await further study. This is because to date, investigators have studied the biologic activities of what was previously thought to be PAF, i.e., only 16:0- and 18:0-AGEPC. In view of the evidence presented in this review, a comprehensive investigation of the possible biologic relevance and significance of PAF molecular heterogeneity is warranted. Hopefully, such studies will be designed to elucidate the extent to which the various molecular species of PAF differ in their intrinsic in vitro and in vivo (patho)physiologic behaviors (agonistic, synergistic, and possibly antagonistic) and modes of action. Once this additional information has been derived, the pathobiologic relevance of this class of phospholipid autacoid may be better understood.

AB - The existence and potential (patho)physiologic significance of PAF molecular heterogeneity can no longer be summarily dismissed or ignored. While significant advances in the chemistry of PAF have been made, the (patho)physiologic behaviors of most of the PAF molecular species of biologic origin await further study. This is because to date, investigators have studied the biologic activities of what was previously thought to be PAF, i.e., only 16:0- and 18:0-AGEPC. In view of the evidence presented in this review, a comprehensive investigation of the possible biologic relevance and significance of PAF molecular heterogeneity is warranted. Hopefully, such studies will be designed to elucidate the extent to which the various molecular species of PAF differ in their intrinsic in vitro and in vivo (patho)physiologic behaviors (agonistic, synergistic, and possibly antagonistic) and modes of action. Once this additional information has been derived, the pathobiologic relevance of this class of phospholipid autacoid may be better understood.

UR - http://www.scopus.com/inward/record.url?scp=0027723521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027723521&partnerID=8YFLogxK

M3 - Article

C2 - 8264227

AN - SCOPUS:0027723521

VL - 69

SP - 639

EP - 650

JO - Laboratory Investigation

JF - Laboratory Investigation

SN - 0023-6837

IS - 6

ER -