Abstract
Paclitaxel and G-CSF have been evaluated for HPC mobilization in breast cancer and found to have tolerable toxicity with a predictable time to initiate leukapheresis. However, this approach has not been reported in patients with hematologic malignancies failing prior mobilization. We report a case-series of 26 adults given paclitaxel and G-CSF for HPC mobilization after failure of an initial mobilization. Patients received paclitaxel 250 mg/m2 followed by G-CSF 10-16 mcg/kg/day. Compared to the initial regimen, paclitaxel mobilization produced greater CD34+ cell yields (median 1.53×106 CD34+ cells/kg vs. 0.79×106 CD34+ cells/kg, p=0.004). Seventy-six percent of patients initiated leukapheresis on day 8, the remainder on day 9 or 10. Three patients developed febrile neutropenia resulting in one death prior to leukapheresis. Overall, 73% of patients proceeded with autologous HPC transplant. This case-series suggests paclitaxel may be an option for HPC mobilization in patients failing prior regimens.
Original language | English (US) |
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Pages (from-to) | 2360-2366 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 48 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2007 |
Keywords
- Hematopoietic stem cell
- Leukapheresis
- Marrow and stem cell transplantation
- Paclitaxel
- Stem cell mobilization
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research