Packaging of non-coding RNAs into herpesvirus virions: Comparisons to coding RNAs

Melanie A. Amen, Anthony Griffiths

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations

    Abstract

    The herpesviruses are a family of large DNA viruses capable of establishing lifelong infections. Recent reports have shown that herpesviruses package non-coding RNA into virions; this follows earlier observations showing that coding RNAs are detected in virions. Packaging RNAs allows for their function immediately after virus entry and in the absence of de novo transcription. Despite the collective understanding that RNAs are packaged into herpesvirus virions, many questions remain. This review will highlight what is known regarding packaged coding and non-coding RNAs and discuss their potential impact to virus biology.

    Original languageEnglish (US)
    Article numberArticle 81
    JournalFrontiers in Genetics
    Volume2
    Issue numberNOV
    DOIs
    StatePublished - Dec 1 2011

    Keywords

    • Herpesvirus
    • Virion

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Genetics(clinical)

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