Abstract
Objective: To determine the change in pachydermia/posterior commissure hypertrophy in patients with laryngopharyngeal reflux disease (LPR) on long-term acid-suppressive therapy. Study Design: Retrospective chart review. Methods: Seventeen patients with LPR who were compliant with long-term acid-suppressive treatment and had good control of their symptoms for at least 20 months were examined. Pre-and posttreatment still laryngeal images from these patients were analyzed by five otolaryngologists blinded to patient information and were scored for pachydermia/posterior commissure hypertrophy according to the Reflux Finding Score (RFS) subset. Test-retest intraobserver reliability, intergrader correlations, as well as a paired t test for means of the data sets were then calculated. Results: There was no significant difference in the grading scores between the pre- and posttreatment group for degree of pachydermia/posterior commissure hypertrophy despite a prolonged treatment interval (mean = 32 months) (P = .25). Conclusions: There is no statistically significant difference in the degree of pachydermia/posterior commissure hypertrophy found at diagnosis and after long-term acid suppressive therapy in patients with LPR. Therefore, it appears that pachydermia, as an isolated finding, is unreliable in determining the presence of active LPR.
Original language | English (US) |
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Pages (from-to) | 1557-1561 |
Number of pages | 5 |
Journal | Laryngoscope |
Volume | 114 |
Issue number | 9 I |
DOIs | |
State | Published - Sep 1 2004 |
Keywords
- Gastroesophageal reflux disease
- Laryngopharyngeal reflux
- Pachydermia
- Reflux laryngitis
ASJC Scopus subject areas
- Otorhinolaryngology