Pachydermia is not diagnostic of active laryngopharyngeal reflux disease

R. Keith Hill, C. Blake Simpson, Ruben Velazquez, Nicole Larson

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Objective: To determine the change in pachydermia/posterior commissure hypertrophy in patients with laryngopharyngeal reflux disease (LPR) on long-term acid-suppressive therapy. Study Design: Retrospective chart review. Methods: Seventeen patients with LPR who were compliant with long-term acid-suppressive treatment and had good control of their symptoms for at least 20 months were examined. Pre-and posttreatment still laryngeal images from these patients were analyzed by five otolaryngologists blinded to patient information and were scored for pachydermia/posterior commissure hypertrophy according to the Reflux Finding Score (RFS) subset. Test-retest intraobserver reliability, intergrader correlations, as well as a paired t test for means of the data sets were then calculated. Results: There was no significant difference in the grading scores between the pre- and posttreatment group for degree of pachydermia/posterior commissure hypertrophy despite a prolonged treatment interval (mean = 32 months) (P = .25). Conclusions: There is no statistically significant difference in the degree of pachydermia/posterior commissure hypertrophy found at diagnosis and after long-term acid suppressive therapy in patients with LPR. Therefore, it appears that pachydermia, as an isolated finding, is unreliable in determining the presence of active LPR.

Original languageEnglish (US)
Pages (from-to)1557-1561
Number of pages5
Issue number9 I
StatePublished - Sep 1 2004


  • Gastroesophageal reflux disease
  • Laryngopharyngeal reflux
  • Pachydermia
  • Reflux laryngitis

ASJC Scopus subject areas

  • Otorhinolaryngology


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